Publications by authors named "Josephine Christine Dorsman"
Detection of cytogenetic changes and chromosomal aneuploidy with fluorescent in situ hybridization in cytological specimens of oral cancers in Fanconi anemia-Proof of concept.
Bruno Eduardo Silva de Araujo Eunike Velleuer Ralf Dietrich Natalia Pomjanski Isabela Karoline de Santana Almeida Araujo Josephine Christine Dorsman
Clin Exp Dent Res
February 2022
Article Synopsis
- Fanconi anemia (FA) is a genetic disorder that greatly increases the risk of certain cancers, particularly oral squamous cell carcinoma (OSCC), which often precedes visible lesions in the mouth.* -
- This study utilized fluorescent in situ hybridization (FISH) to analyze genetic changes in OSCC specimens and brush biopsies from FA-affected individuals, revealing widespread chromosomal aneuploidy and specific genetic alterations.* -
- The findings suggest that FISH can effectively distinguish between malignant and non-malignant oral lesions in FA patients, highlighting its potential use in cancer detection through oral cytology.*