Publications by authors named "Josephine C Gollin"
ERK phosphorylation is dependent on cell adhesion in a subset of pediatric sarcoma cell lines.
Biochim Biophys Acta Mol Cell Res
August 2022
Article Synopsis
- Osteosarcoma (OS) and Pax-Foxo1 fusion negative rhabdomyosarcoma (FN-RMS) are serious pediatric cancers known for their poor outcomes, especially in advanced stages, with a focus on the role of actin binding proteins in worsening prognosis.
- The study investigates how integrin adhesion complexes (IACs) and actin dynamics influence ERK activation in different cell lines from OS and FN-RMS, revealing varied adhesion-dependent responses between the two cancer types.
- Findings indicate that ERK phosphorylation is not consistently affected by adhesion in OS cells, while in FN-RMS, adhesion boosts ERK activation and points to distinct mechanisms of cell signaling that differ from existing models observed in other cancers.