Publications by authors named "Joseph Welk"
Article Synopsis
- The study focuses on the reactivation and dissemination of viruses in vulnerable patient populations, such as those with cancer or undergoing immunosuppressive therapy.
- A new assay combining PCR and mass spectrometry was developed to accurately and simultaneously identify multiple viruses directly from plasma samples.
- The assay showed high sensitivity and specificity, detecting additional viral infections not previously identified by standard tests, thus enhancing diagnostic capabilities in clinical settings.
This study examines how age affects the first phase of the heat shock response in human T-cells. To understand how age alters transcriptional regulation of the heat shock genes, a cross-sectional study was conducted utilizing human T-cells enriched from peripheral blood lymphocytes of healthy young (20-40 years old) and old (>70 years old) donors. Nuclear run-on analysis revealed a 66% reduction in hsp70 transcription rates in old compared to young nuclei harvested from T-cells exposed to a brief 42 degrees C heat shock.
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