An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors.

Rationale, Aims And Objectives: To identify potential factors leading to discontinuation of angiotensin-converting enzyme (ACE) inhibitors because of adverse drug events.

Methods: Retrospective cohort study was conducted at outpatient clinics affiliated with an urban tertiary care hospital. ACE inhibitors were administered to 2225 consecutive outpatients.

Development and validation of a clinical prediction rule for angiotensin-converting enzyme inhibitor-induced cough.

Background: Angiotensin-converting enzyme inhibitors are effective for many cardiovascular diseases and are widely prescribed, but cough sometimes necessitates their withdrawal.

Objective: To develop and validate a model that predicts, by using information available at first prescription, whether a patient will develop cough within 6 months.

Design: Retrospective cohort study with derivation and validation sets.