Frequency of Alleles Including Structural Variants in the United States.

The gene encodes an enzyme important in the metabolism of many commonly used medications. Variation in is associated with inter-individual differences in medication response, and genetic testing is used to optimize medication therapy. This report describes a retrospective study of allele frequencies in a large population of 104,509 de-identified patient samples across all regions of the United States (US).

Phase I trial of adoptive immunotherapy with cytolytic T lymphocytes immunized against a tyrosinase epitope.

Purpose: To study distribution and toxicity of cytolytic T lymphocytes (CTLs) against a single melanoma epitope.

Patients And Methods: CD8(+) T cells obtained by leukapheresis from 10 patients with disseminated HLA-A2.1(+), tyrosinase-positive melanomas were immunized in vitro against tyrosinase(369-377) (YMNGTMSQV).