Vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation in the heart.

In the heart, cell-matrix and cell-cell adhesions reorganize in response to increased cardiac demand and growth to promote cardiomyocyte maturation. Vinculin, a mechanosensitive adaptor protein, links filamentous actin to cell-matrix and cell-cell adhesions and is thus positioned to regulate adhesion reorganization. However, how the two adhesion systems are coordinated in the heart, and the role of vinculin in this process is poorly understood.

Long-range-interacting topological photonic lattices breaking channel-bandwidth limit.

The presence of long-range interactions is crucial in distinguishing between abstract complex networks and wave systems. In photonics, because electromagnetic interactions between optical elements generally decay rapidly with spatial distance, most wave phenomena are modeled with neighboring interactions, which account for only a small part of conceptually possible networks. Here, we explore the impact of substantial long-range interactions in topological photonics.

Photonic Topological Spin Pump in Synthetic Frequency Dimensions.

Reducing geometrical complexity while preserving desired wave properties is critical for proof-of-concept studies in wave physics, as evidenced by recent efforts to realize photonic synthetic dimensions, isospectrality, and hyperbolic lattices. Laughlin's topological pump, which elucidates quantum Hall states in cylindrical geometry with a radial magnetic field and a time-varying axial magnetic flux, is a prime example of these efforts. Here we propose a two-dimensional dynamical photonic system for the topological pumping of pseudospin modes by exploiting synthetic frequency dimensions.