Publications by authors named "Joseph Schnier"
Lung allograft dysbiosis associates with immune response and primary graft dysfunction.
J Heart Lung Transplant
November 2024
Article Synopsis
- Lower airway dysbiosis, characterized by an increase in specific bacteria, is linked to various severity grades of primary graft dysfunction (PGD) after lung transplantation, particularly in moderate and severe cases.
- A study involving lower airway samples from 96 lung transplant recipients showed correlations between PGD severity and elevated levels of inflammatory markers, particularly neutrophils and specific cytokines, indicating a distinct inflammatory response.
- Results suggest that microbial differences may influence host immune signaling, potentially exacerbating inflammation and contributing to PGD pathogenesis, highlighting the importance of microbial balance in lung health post-transplant.
Acute cellular rejection (ACR) after lung transplant is a leading risk factor for chronic lung allograft dysfunction. Prior studies have demonstrated dynamic microbial changes occurring within the allograft and gut that influence local adaptive and innate immune responses. However, the lung microbiome's overall impact on ACR risk remains poorly understood.
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