Digitally Driven Short- and Intermediate-term Courses of Primary Care Psychiatry for Doctors: A Theme-based Analysis and Performance Audit.

Background: The National Mental Health Survey of India 2015-2016 identified a substantial treatment gap in mental healthcare, emphasizing the urgent need for improved training of primary care doctors (PCDs) in managing psychiatric disorders. This study aimed to evaluate the effectiveness of three digitally delivered primary care psychiatry courses offered by the department of psychiatry in a tertiary neuropsychiatric center: the Certificate Course in Primary Mental Healthcare (CCPMH), the Diploma in Community Mental Health (DCMH), and the Diploma in Primary Care Psychiatry (DPCP).

Methods: Based on the board of studies documents, including curriculum, delivery methods, accreditation criteria, and outcomes, a comparative and thematic analysis of the courses was conducted.

Publication of studies registered in Clinical Trials Registry of India: An audit of mood disorder research protocols from 2009-2019.

Background: Selective publication of studies has important scientific, ethical, and public health implications.

Aim: We studied selective publication among mood disorder research protocols registered in the Clinical Trials Registry of India (CTRI) database. We also examined the frequency and nature of protocol deviations among the published articles.

Incidence and prevalence of depressive, anxiety, and insomnia symptoms among adult liver transplant recipients: A systematic review and meta-analysis.

Objective: Psychological morbidity among transplant recipients may negatively impact post-transplantation outcomes. Our objectives were to compute pooled incidence and prevalence estimates for depressive, anxiety, and insomnia symptoms among adults who underwent liver transplant.

Methods: Electronic searches of MEDLINE, PubMed Central, CINAHL, and Google Scholar were carried out from inception to October 2022 to identify observational studies conducted among adult liver transplant recipients which measured depression, anxiety, and/or insomnia.

Predictive validity of ESSENCE Q screening tool for early detection of neurodevelopmental disorder in children.

Introduction: Neurodevelopmental disorders (NDD) are a group of conditions that typically manifest early during the child's development with lifelong consequences. Early identification using efficient screening tools can positively modify the natural history of the disorder. ESSENCE Q is a simple questionnaire to detect ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations to reflect the co-existence of NDDs in children less than five years).

Vermitransformation of monogastric Elephas maximus and ruminant Bos taurus excrements into vermicompost using Eudrilus eugeniae.

Biotransformation of monogastric (Elephas maximus) and ruminant (Bos taurus) excrements with Eudrilus eugeniae was assessed by establishing five different treatments in triplicate: 100% elephant dung (T1), 50% elephant dung + 50% garden soil (T2), 50% elephant dung + 50% cow dung (T3), 100% cow dung (T4) and 50% cow dung + 50% garden soil (T5) and maintained for 90 days under experimental conditions. An increment of macronutrients and reduction of C/N ratio (<20) in the vermicomposts was recorded, where T3 presented higher NPK contents with the relative nutrient recovery efficiency of 1.65, 2.

Nutrient recovery and vermicompost production from livestock solid wastes with epigeic earthworms.

The aim of this work was to study nutrient recovery and vermicompost production from livestock solid wastes of indigenous and exotic cow breeds with epigeic earthworms. Fourteen days pre-decomposed dung of Vechur native (CD1) and exotic Jersey (CD2) breeds were vermicomposted with Perionyx excavatus and Eudrilus eugeniae for 45 days (Cycle I) and 90 days (Cycle II) including respective controls without earthworms. Vermicomposts from CD1 and CD2 substrates during Cycle I and II showed increase in NPK, Ca and micro-nutrients (P < 0.

Hollow Microcapsules as Periocular Drug Depot for Sustained Release of Anti-VEGF Protein.

Diseases affecting the posterior segment of the eye such as age-related macular degeneration and diabetic retinopathy are leading causes of blindness all over the world. The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. This method is highly invasive and can lead to severe complications.

Characterization of liposomal carriers for the trans-scleral transport of Ranibizumab.

Age-related macular degeneration (AMD) is a leading cause of blindness in the modern world. The standard treatment regimen for neovascular AMD is the monthly/bimonthly intravitreal injection of anti-VEGF agents such as ranibizumab or aflibercept. However, these repeated invasive injections can lead to sight-threatening complications.

Drug delivery to the eye: what benefits do nanocarriers offer?

Ocular drug delivery has seen several advances in the past few decades, with respect to new drugs, improved formulations, targeted delivery, as well as exploration of new routes of drug administration. New materials have been explored for encasing existing drugs, which can enhance treatment by increasing bioavailability, decreasing toxicity, providing better tissue adherence, targeted delivery as well as increased duration of action. The challenges and requirements are different for the anterior and posterior ocular segments.