Publications by authors named "Joseph R Zoeller"
Article Synopsis
- MYC is a critical driver of cancer that enhances gene expression and increases RNA production, contributing to tumor growth and survival.
- The study reveals that MYC triggers RNA degradation, leading to toxic byproducts that cause cancer cell death, indicating a new mechanism for targeting MYC-driven cancers.
- Therapeutic strategies that intensify the breakdown of RNA could serve as effective treatments for aggressive cancers like triple-negative breast cancer (TNBC) that rely on MYC.
We report that when Ir and La halides are deposited on carbon, exposure to CO spontaneously generates a discrete molecular heterobimetallic structure, containing an Ir-La covalent bond that acts as a highly active, selective, and stable heterogeneous catalyst for the carbonylation of methanol to produce acetic acid. This catalyst exhibits a very high productivity of ∼1.5 mol acetyl/mol Ir·s with >99% selectivity to acetyl (acetic acid and methyl acetate) without detectable loss in activity or selectivity for more than 1 month of continuous operation.
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