Publications by authors named "Joseph Pm Kane"
Background: Prodromal dementia with Lewy bodies (DLB) research criteria were recently published and further work is needed to characterize the neuropsychological profile and refine clinical criteria. We performed a meta-analysis to compare the cognitive performance of mild cognitive impairment with Lewy bodies (MCI-LB) groups to controls, MCI due to Alzheimer's disease (MCI-AD), and DLB.
Method: Following PRISMA guidelines, we searched the literature for 1) English-language studies on MCI-LB; 2) published January 1990-March 2023, 3) with ≥1 standardized cognitive measure; and 4) comparison data from controls, MCI-AD, and/or DLB.
Article Synopsis
- - A systematic review and meta-analysis were conducted to evaluate the diagnostic features and biomarkers for mild cognitive impairment with Lewy bodies (MCI-LB) based on criteria published in 2020.
- - The analysis included data from 57 articles, supporting the inclusion of current clinical features in the criteria and suggesting that striatal dopaminergic imaging and cardiac scintigraphy may also be beneficial, though evidence is limited.
- - The findings indicate that the core clinical features are more prevalent in MCI-LB compared to MCI due to Alzheimer's disease, and while some biomarkers like FDG-PET and quantitative EEG are promising, further research is needed.
Dementia with Lewy bodies (DLB) is an important cause of dementia with a range of clinical manifestations, including motor, neuropsychiatric, and autonomic symptoms. Compared with more common forms of dementia such as Alzheimer's disease, DLB has been the focus of significantly fewer treatment studies, often with diverse outcome measures, making comparison and clinical implementation difficult. A core outcome set (COS) can address this by ensuring that data are comparable, relevant, useful, and usable for making the best healthcare decisions.
View Article and Find Full Text PDF