Publications by authors named "Joseph Paul"

Absorbable hemostatic agents are commonly used in clinical practice and their imaging appearance is less known. In our case series, we demonstrate how absorbable hemostatic agents can masquerade as other clinically and medicolegally significant conditions such as gossypiboma and infected collections. Through our report, we aimed to describe the imaging features of absorbable hemostatic agents, to compare them with their imaging mimics, and provide a comprehensive review of the available literature.

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While the effects of external factors like fluid mechanical forces and scaffold geometry on tissue growth have been extensively studied, the influence of cell behavior-particularly nutrient consumption and depletion within the scaffold-has received less attention. Incorporating such factors into mathematical models allows for a more comprehensive understanding of tissue-engineering processes. This work presents a comprehensive continuum model for cell proliferation within two-dimensional tissue-engineering scaffolds.

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We present a case of insatiable appetite and harmful overeating in a hospice patient that showcases the burden of hypothalamic hyperphagia, a rare complication of brain cancer. While confounders exist such as progression of disease and prior tapering of dexamethasone, in this case the initiation of metformin was associated with substantial appetite reduction and resolution of our patient's debilitating food-seeking behaviors. We will explore metformin as a potential cost-effective option for palliation in a hospice setting and explore some of the physiologic mechanisms involved.

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Local protein synthesis in axons and dendrites underpins synaptic plasticity. However, the composition of the protein synthesis machinery in distal neuronal processes and the mechanisms for its activity-driven deployment to local translation sites remain unclear. Here, we employed cryo-electron tomography, volume electron microscopy, and live-cell imaging to identify Ribosome-Associated Vesicles (RAVs) as a dynamic platform for moving ribosomes to distal processes.

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Article Synopsis
  • - The study focuses on evaluating how oxygen extraction fraction (OEF) and deoxyhemoglobin (DoHb) levels indicate variations in brain metabolism among patients with different stages of dementia, using advanced MRI techniques.
  • - Researchers employed a multi-echo gradient-echo (mGRE) MRI scan on a powerful 3.0 Tesla scanner to perform a detailed analysis, requiring simplifications of the qBOLD model to enhance data relevance.
  • - The investigation utilized existing MRI data from Alzheimer’s, mild cognitive impairment, and healthy patients to assess brain metabolism, validating its results through statistical methods and clustering techniques.
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Purpose: There are a number of algorithms for smooth -norm (SL0) approximation. In most of the cases, sparsity level of the reconstructed signal is controlled by using a decreasing sequence of the modulation parameter values. However, predefined decreasing sequences of the modulation parameter values cannot produce optimal sparsity or best reconstruction performance, because the best choice of the parameter values is often data-dependent and dynamically changes in each iteration.

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Oncogenic mutations can destabilize signaling proteins, resulting in increased or unregulated activity. Thus, there is considerable interest in mapping the relationship between mutations and the stability of signaling proteins, to better understand the consequences of oncogenic mutations and potentially inform the development of new therapeutics. Here, we develop a tool to study protein-kinase stability in live mammalian cells and the effects of the HSP90 chaperone system on the stability of these kinases.

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Direct oral factor Xa inhibitors are replacing vitamin K-dependent antagonists as anticoagulation treatment in many clinical scenarios. Trauma centers are noting an increase in patients presenting on these medications. The 2018 Food and Drug Administration approval of andexanet alfa provides an alternative anticoagulation reversal.

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Photocatalytic water purification has been extensively explored for its economic, eco-friendly, and sustainable aspects. In this study, tungsten (W) incorporated BaSnWO (x = 0 to 0.05) nanoparticles synthesized by facile hydrogen peroxide precipitation route has been demonstrated for photocatalytic degradation of methylene blue (MB) dye and ciprofloxacin (CIP) antibiotic.

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Oncogenic mutations can destabilize signaling proteins, resulting in increased or unregulated activity. Thus, there is considerable interest in mapping the relationship between mutations and the stability of proteins, to better understand the consequences of oncogenic mutations and potentially inform the development of new therapeutics. Here, we develop a tool to study protein-kinase stability in live mammalian cells and the effects of the HSP90 chaperone system on the stability of these kinases.

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Purpose: To develop a method for unwrapping temporally undersampled and nonlinear gradient recalled echo (GRE) phase.

Theory And Methods: Temporal unwrapping is performed as a sequential one step prediction of the echo phase, followed by a correction to the nearest integer wrap-count. A spatio-temporal extension of the 1D predictor corrector unwrapping (PCU) algorithm improves the prediction accuracy, and thereby maintains spatial continuity.

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Article Synopsis
  • Optometrists who use optical coherence tomography (OCT) as a standard tool are more likely to refer patients for specialized glaucoma care compared to those who do not use OCT.
  • A study using electronic medical records from 331 optometry practices in Australia analyzed referrals for glaucoma assessments between practices using OCT and those without it.
  • Results showed that referrals for glaucoma were significantly higher in OCT practices, with an adjusted odds ratio indicating a 39% increased likelihood of referral for those using OCT.
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In this paper, we present the development of a novel processing technology to tackle hard-to-recycle plastic packaging waste contaminated with food residues. The proof-of-concept (POC) technology can effectively separate food residual amounts from plastic waste materials to a level acceptable for further re-use or recycling of the plastic packaging. To assess this technology, we have conducted spectroscopic, thermal, and calorimetric characterizations of the obtained fractions, such as cleaned mixed plastics (CMP), food waste with mixed plastics (FWMP), and a mixture of microplastics (MP).

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Hepatic zonation is critical for most metabolic functions in liver. Wnt signaling plays an important role in establishing and maintaining liver zonation. Yet, the anatomic expression of Wnt signaling components, especially all 10 Frizzled (Fzd) receptors, has not been characterized in adult liver.

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Polystyrene (PS) was modified by covalently binding P-, P-N- and/or N- containing fire-retardant moieties through co- or ter-polymerization reactions of styrene with diethyl(acryloyloxymethyl)phosphonate (DEAMP), diethyl--vinylbenzyl phosphonate (DEpVBP), acrylic acid-2-[(diethoxyphosphoryl)methylamino]ethyl ester (ADEPMAE) and maleimide (MI). In the present study, the condensed-phase and the gaseous-phase activities of the abovementioned fire retardants within the prepared co- and ter-polymers were evaluated for the first time. Pyrolysis-Gas Chromatography/Mass Spectrometry was employed to identify the volatile products formed during the thermal decomposition of the modified polymers.

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The building and construction industry consumes a significant amount of virgin resources and minimizing the demand with alternative waste materials can provide a contemporary solution. In this study, thermal components of kraft fibres (KFs) derived from waste cardboard are investigated. The mechanical properties containing KFs within concrete composites are evaluated.

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Myocardial infarction is one of the major life-threatening diseases. The cause is atherosclerosis i.e.

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In this paper, we report on the thermal degradation behaviours and combustion attributes of some polymers based on polystyrene (PSt). Here, both additive and reactive strategies were employed, through the bulk polymerization route, where the modifying groups incorporated P-atom in various chemical environments. These included oxidation states of III or V, and the loading of phosphorus was kept at ca.

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The thermal and calorimetric characterizations of polymethyl methacrylate-based polymers are reported in this paper. The modifying groups incorporated the phosphorus atom in various chemical environments, including oxidation states of III, or V. Both additive and reactive strategies were employed, where the loading of phosphorus was kept at 2 wt% in all cases.

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Objective: Using physiological markers to detect patients at risk of deterioration is common. Deaths at music festivals in Australia prompted scrutiny of tools to identify critically unwell patients for transport to hospital. This study evaluated initial physiological parameters to identify patients selected for transport to hospital from a music festival.

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A third of deaths in the world are due to cardiovascular diseases [1]. Atherosclerosis is the major cause of myocardial infarction, which occurs by deposition of plaque in the coronary artery. The chance of stroke rises with the thickening of carotid artery due to the plaque.

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The RAS protein activator like 2 (RASAL2) negatively regulates RAS proto-oncogene which is activated by high mutation rate in cancer. Thus, RASAL2 expression could potentially limit the function of RAS in prostate cancer (PCa). Genome-wide DNA methylation analysis demonstrated that RASAL2 is differentially hypermethylated in PCa tissues compared to benign prostate tissues.

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The present paper reports the preliminary results relating to the development, subsequent application, and testing of environmentally benign starch-based formulations for passive fire protection of wood substrates. This study evaluated the effectiveness of starch colloid coatings applied onto the wood surface with a view to improving its performance when exposed to the external heat flux (35 kW/m) during cone calorimetric tests. The formulations were prepared from aqueous colloid solutions of either starch alone, or in combination with inorganic salts, such as: sodium carbonate, NaCO, potassium carbonate, KCO, and diammonium hydrogen phosphate, (NH)HPO.

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The aspects of fire retardation in some phosphorus-modified polymethyl methacrylate (PMMA) and polystyrene (PSt) polymers are reported in the present paper. Both and strategies were employed to obtain the desired level of loading of the phosphorus-bearing compound/moiety (2 wt.% of P in each case).

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