Publications by authors named "Joseph P Portanova"
Article Synopsis
- Exposure to p38alpha MAPK inhibitors in Beagle dogs leads to acute toxicity characterized by symptoms like decreased activity, diarrhea, and fever, alongside severe lymphoid tissue damage and hemorrhages.
- The earliest noticeable changes include lymphocyte death in gut-associated lymphoid tissue, progressing to inflammation and additional tissue damage in lymph nodes and spleen.
- These toxic effects were specific to dogs, as similar observations were not found in other tested species like mice, rats, or monkeys, highlighting the unique response to p38alpha MAPK inhibition in dogs.
Prostaglandin E(2) (PGE(2)) is known to inhibit in vitro T-cell responses to mitogenic and antigenic stimuli. Interaction of PGE(2) with a G protein-coupled receptor activates adenylyl cyclase, leading to cAMP formation and inhibition of interleukin-2 (IL-2) production and T-cell proliferation. Despite these effects, the application of PGE(2) as an anti-inflammatory agent has been compromised by its unfavorable pharmacodynamic and side-effect profile.
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