Cisplatin and cranial irradiation-related hearing loss in children.

Background: High doses of cisplatin and cranial radiotherapy (CRT) have been reported to cause irreversible hearing loss. The objective of this study was to examine the influence of cranial irradiation on cisplatin-associated ototoxicity in children with pediatric malignancies.

Methods: Serial audiograms were obtained for 33 children, age <16 years, treated with cisplatin-based chemotherapy (90-120 mg/m(2) per cycle) with or without CRT.

Medulloblastoma variants and survival at a children's hospital.

Our 25 year experience with 35 medulloblastomas included classic (NOS) 22 (63%), anaplastic (ANA) 5(14%), desmoplastic (DES) 4(11%), excessive nodularity (EN) 3(9%), and large cell (LC) 1(3%). Overall 5, 10, and 15 year survivals were .6631, .

GMFM 1 year after continuous intrathecal baclofen infusion.

The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years.

Hip status in cerebral palsy after one year of continuous intrathecal baclofen infusion.

The purpose of this study was to assess whether reduction of muscle tone by continuous intrathecal baclofen infusion affects the progression of hip subluxation in persons with cerebral palsy. This prospective, open-label, case series was conducted at multiple specialty referral centers. There were 33 subjects, ages 4 to 31 years.

Congenital glaucoma and neurofibromatosis in a monozygotic twin: case report and review of the literature.

We describe a dramatic case of an identical twin presenting at birth with unilateral congenital glaucoma. Because of the suspicion of neurofibromatosis 1 a magnetic resonance image of the neural axis was obtained, which revealed a plexiform neurofibroma with spinal cord impingement. Diagnosis of neurofibromatosis 1 was confirmed by 3 months of age with the emergence of café-au-lait spots.

Hydrocephalus.

In treating patients with hydrocephalus, cerebral ventricular shunts and their complications are often encountered by the primary care provider. Caring for these patients can provoke anxiety and doubt in those who have had little exposure in dealing with shunts. Becoming familiar with the clinical findings, etiology, and treatment of hydrocephalus, as well as the signs and symptoms of cerebral ventricular shunt complications, will aid the primary care physician in the management, treatment, referral, and continuing care of these patients.