Small cell carcinoma of the endometrium: light microscopic and immunohistochemical study of a case.

Small cell carcinoma of the endometrium is extremely rare. The clinical behaviour of this tumour is usually very aggressive. The histopathological distinction of endometrial small cell neuroendocrine carcinoma from mesodermal mixed tumours has important prognostic and therapeutic implications.

Skin-sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction is an oncologically safe procedure.

Objective: Is skin-sparing mastectomy (SSM) with conservation of the Nipple-Areola Complex (NAC) and immediate autologous reconstruction as safe in oncologic terms as SSM with resection of the NAC as modified radical mastectomy (MRM)?

Summary Background Data: The originally described technique of SSM included the removal of gland, NAC, and biopsy scar. However, the risk of tumor involvement of NAC in patients with breast cancer has been overestimated.

Patients And Methods: Between 1994 and 2000, 286 selected patients with an indication for MRM and tumor margins of greater than 2 cm from the nipple were presented with the alternative of a SSM.