Publications by authors named "Joseph M McCrate"
A technique enabling the detection and quantification of low density sites on planar SiO2 surfaces is demonstrated. Fluorescent probes are used to titrate free hydroxyl and strained siloxane sites on the surface of amorphous SiO2 substrates in vacuum. The titration of free hydroxyl sites was performed to validate the method and to provide a reference for the measurement of the strained siloxane site density.
View Article and Find Full Text PDFThe objective of this study is to evaluate the effect of hydroxyapatite (HAP) nanoparticles with different surface charges on the cellular uptake behavior and in vitro cell viability and proliferation of MC3T3-E1 cell lines (osteoblast). The nanoparticles' surface charge was varied by surface modification with two carboxylic acids: 12-aminododecanoic acid (positive) and dodecanedioic acid (negative). The untreated HAP nanoparticles and dodecanoic acid modified HAP nanoparticles (neutral) were used as the control.
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- A study investigates bombesin (BBN) as a delivery method for diagnostic probes like 99mTc radiometal to target cancers that over-express gastrin-releasing peptide receptors (GRPr).
- Various amino acid and aliphatic compounds were tested to determine how they affect the targeting agent's ability to bind to receptors and its distribution in tissues.
- The study reveals that some new 99mTc-BBN conjugates show significant effectiveness in targeting prostate cancer tumors in rodent models, suggesting potential for improved cancer imaging techniques.