Effects of aminoguanidine on tissue oxidative stress induced by hindlimb unloading in rats.

We investigated the effects of hindlimb unloading (HLU) on malondialdehyde (MDA), a biomarker for oxidative stress, and glutathione (GSH) levels in tissues of rats. Aminoguanidine (AG), a nucleophilic hydralazine compound and an in vivo antioxidant against reactive oxygen species (ROS) and lipid peroxidation, was used to confirm the HLU-induced oxidative response. Three groups of rats were used: Group 1 was a loaded control group that was maintained on drinking water only; Groups 2 and 3 were hindlimb unloaded (HLU) groups that were maintained on drinking water and on AG in drinking water, respectively.

Latent synthesis of electrically conductive surface-silvered polyimide films.

A facile ambient temperature route to the fabrication of surface silver-metallized polyimide films is described. Silver(I) trifluoromethanesulfonate or silver(I) nitrate and a polyimide, derived from 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride and an equimolar amount of 4,4'-oxydianiline and 3,5-diaminobenzoic acid, were dissolved together in dimethylacetamide. Silver(I)-doped films were prepared at thicknesses of 25-40 microm and depleted of solvent by evaporation at ambient temperature and low humidity.