Risk stratification of patients in an emergency department chest pain unit: prognostic value of exercise treadmill testing using the Duke score.

Background: Exercise treadmill testing (ETT) has been standard for evaluating outpatients at risk for cardiovascular events. Few studies have demonstrated its prognostic usefulness in emergency department chest pain units or have used the Duke score [(exercise duration in minutes) - (5 x ST-segment deviation in millimeters) - (4 x treadmill angina index)] to grade its performance.

Aims: Our objective was to assess the usefulness of this score in a chest pain unit to predict cardiovascular events.

A prospective, randomized trial of an emergency department observation unit for acute onset atrial fibrillation.

Study Objective: An emergency department (ED) observation unit protocol for the management of acute onset atrial fibrillation is compared with routine hospital admission and management.

Methods: Adult patients presenting to the ED with atrial fibrillation of less than 48 hours' duration without hemodynamic instability or other comorbid conditions requiring hospitalization were enrolled. Participants were randomized to either ED observation unit care or routine inpatient care.

Challenges, controversies, and advances in aortic catastrophes.

Emergency physicians (EPs) are commonly faced with life-threatening entities. Particularly challenging are the aortic catastrophes, such as penetrating aortic ulcers (PAUs), intramural hematomas (IMHs), and atypical presentations of acute aortic dissections and ruptured abdominal aortic aneurysms. Several factors account for this: (1) the rapidly evolving knowledge (particularly in the pathogenesis and precursors of aortic dissection [AD]), (2) the lack of comfort caused by infrequent exposure, (3) the misconceptions about the work up and treatment, (4) the lack of emergent vascular surgery back up in the community, and finally (5) the high short-term mortality and missed rates.

A randomized, double-blinded, placebo-controlled, dose-ranging study measuring the effect of an adenosine agonist on infarct size reduction in patients undergoing primary percutaneous transluminal coronary angioplasty: the ADMIRE (AmP579 Delivery for Myocardial Infarction REduction) study.

Background: Evidence suggests that myocardial ischemic preconditioning and reperfusion injury may be mediated by adenosine A1 and A2 receptors. AMP579 is a mixed adenosine agonist with both A1 and A2 effects. In animal models of acute myocardial infarction (MI), AMP579 reduced infarct size at serum levels of 15 to 24 ng/mL.