Publications by authors named "Joseph I Thomson"
Front Cell Dev Biol
April 2021
Article Synopsis
- The enhancer SBE2 plays a crucial role in regulating gene expression within the embryonic brain, particularly in the rostral diencephalon, affecting development without causing major visible anatomical defects initially.
- Deletion of SBE2 revealed compensatory secondary enhancer activity that allows for low levels of expression, which shows its importance in maintaining necessary gene levels for normal brain and craniofacial development.
- Disruptions in SBE2-related expression led to issues in hypothalamic and craniofacial development, underscoring its role in ensuring coordinated morphogenesis of both brain regions and adjacent skull structures.
