Publications by authors named "Joseph Grisanti"

Article Synopsis
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs and often leads to serious kidney issues characterized by proteinuria.
  • Traditional treatments like anti-inflammatory drugs and corticosteroids sometimes fail to effectively manage the condition, leaving patients with limited options.
  • In a groundbreaking case, a 41-year-old woman with resistant SLE symptoms saw significant improvement after being treated with canakinumab, resulting in reduced fever frequency, lower proteinuria, and improved kidney function, suggesting it could be a new effective therapy for patients who haven't responded to standard treatments.
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Background Current literature evaluating the effect of high body mass index (BMI) on the disease activity of patients with rheumatoid arthritis (RA) is mixed as some studies have shown a positive, linear relationship between BMI and disease activity while others have demonstrated an inverse correlation. Through this study, we have expanded the effect of BMI on disease activity in patients with RA. We have further expanded on whether BMI influences the disease activity depending on the gender being studied.

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Objective: Two surveys were conducted with patients with rheumatologic diseases to evaluate perceptions of different routes of administration (intravenous [IV] or subcutaneous [SC]) for biologic therapy.

Methods: In Survey I, patient preferences toward biologic treatment were evaluated at a rheumatology practice in Buffalo, New York. In Survey II, Canadian patients enrolled in the BioAdvance patient support program and scheduled to receive IV biologic therapy were asked about their opinions of IV treatment.

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The major objectives in treating patients with rheumatoid arthritis are managing the symptoms of disease and preserving joint structure, with the ultimate goal of disease remission. Several independent studies have shown that treatment decisions driven by quantitative rather than subjective monitoring of disease activity result in significantly improved patient outcomes. Various assessment tools are available that measure both clinical and patient-reported outcomes.

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