Publications by authors named "Joseph Griffiths"
Background: Understanding antibody responses to SARS-CoV-2 vaccination is crucial for refining COVID-19 immunization strategies. Generation of mucosal immune responses, including mucosal IgA, could be of potential benefit to vaccine efficacy; however, limited evidence exists regarding the production of mucosal antibodies following the administration of current mRNA vaccines to young children.
Methods: We measured the levels of antibodies against SARS-CoV-2 from a cohort of children under 5 years of age (n = 24) undergoing SARS-CoV-2 mRNA vaccination (serially collected, matched serum and saliva samples) or in a convenience sample of children under 5 years of age presenting to pediatric emergency department (nasal swabs, n = 103).
Background: Understanding antibody responses to SARS-CoV-2 vaccination is crucial for refining COVID-19 immunization strategies. Generation of mucosal immune responses, including mucosal IgA, could be of potential benefit to vaccine efficacy, yet limited evidence exists regarding the production of mucosal antibodies following the administration of current mRNA vaccines to young children.
Methods: We measured the levels of antibodies against SARS-CoV-2 from a cohort of children under 5 years of age undergoing SARS-CoV-2 mRNA vaccination (serially collected, matched serum and saliva samples, N=116) or on convenience samples of children under 5 years of age presenting to a pediatric emergency department (nasal swabs, N=103).
Plants employ immunological and ecological strategies to resist biotic stress. Recent evidence suggests that plants adapt to biotic stress by changing their root exudation chemistry to assemble health-promoting microbiomes. This so-called 'cry-for-help' hypothesis provides a mechanistic explanation for previously characterized soil feedback responses to plant disease, such as the development of disease-suppressing soils upon successive cultivations of take all-infected wheat.
View Article and Find Full Text PDFBackground: This study examines associations between pedometer-determined steps/day and parent-reported child's Body Mass Index (BMI) and time typically spent watching television between school and dinner.
Methods: Young people (aged 5-19 years) were recruited through their parents by random digit dialling and mailed a data collection package. Information on height and weight and time spent watching television between school and dinner on a typical school day was collected from parents.
Background: The Joint Canada/United States Survey of Health (JCUSH) was a one-time collaborative survey undertaken by Statistics Canada and the National Center for Health Statistics.
Methods: This analysis provides country-, sex-, and age-specific comparative markers of adult obesity and sedentarism, defined as independent and collective groupings of self-reported leisure-time inactivity (<1.5 MET-hours/day), usual occupational sitting, and no/low active transportation (<1 hour/week).
Descriptive epidemiology of youth pedometer-determined physical activity: CANPLAY.
Med Sci Sports Exerc
September 2010
Purpose: Objective measurement with body worn instrumentation is a preferred and increasingly common way to gather information about young people's physical activity. Measured samples have been typically small and recruited through schools. The purpose of this article was to present the descriptive epidemiology of children and youth pedometer-determined physical activity on the basis of a large national sample.
View Article and Find Full Text PDFObjective: To determine whether use of clinical decision rules or rapid streptococcal antigen detection tests (alone or in combination) can lower the number of unnecessary prescriptions for antibiotics for adults with acute sore throats.
Design: Four-arm randomized controlled trial.
Setting: Family practice offices in eastern Newfoundland.