* Twelve patients were randomized to receive 4-hour or 12-hour HDMTX infusions, with various measurements taken, including serum and urine methotrexate concentrations and kidney function indicators; results showed no significant difference in AKI risk between infusion durations.
* Despite prolonged infusion reducing peak methotrexate levels, AKI biomarkers indicated tubular damage, and while overall tumor response was similar, kidney function declined post-therapy, suggesting