mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity.

Indoleamine-2,3-dioxygenase (IDO)1 degrades tryptophan, obtained through dietary intake, into immunoregulatory metabolites of the kynurenine pathway. Deficiency or blockade of IDO1 results in the enhancement of autoimmune severity in rodent models and increased susceptibility to developing autoimmunity in humans. Despite this, therapeutic modalities that leverage IDO1 for the treatment of autoimmunity remain limited.

Spiritual Awakening in 12-Step Recovery: Impact Among Residential Aftercare Residents.

Spiritually-based interventions in the form of 12-step programs are frequently offered as a part of substance use treatment programs in the United States. Programs based in the 12 steps guarantee that by working their program, an individual will undergo a process of transformation labeled a spiritual awakening. However, the impact of this experience on recovery factors and treatment adherence is unclear.

Reactance, Decisional Procrastination, and Hesitation: A Latent Class Analysis of Clutter Behavior.

During the 2019-2020 global pandemic, mandated time at home suggested engagement in personal projects, such as home decluttering. Clutter (an overabundance of possessions) may impede one's quality of life by interfering with space livability and social connections and prompting negative affect and financial problems. The present study explored action-state orientation, psychological reactance, and decisional procrastination with 227 American adults ( age = 49.

Predictors of e-waste: Considerations for community psychology prevention and intervention.

E-waste, the overabundance of unused technology products, is a growing issue as new technology is rapidly innovated and our society promotes the need to always have the "latest and greatest" products. Community psychology, as a field, is concerned with the global climate crisis, and subsequently must be concerned with e-waste. This study tested predictors of individual's likelihood to recycle e-waste with 883 US adults (459 males, 420 females, 3 other/nonbinary; 62.

Home Away from Home: Comparing Factors Impacting Migrants' and Italians Sense of Psychological Home.

Psychological home is an understudied concept within community psychology, especially focused on migrants. Previous literature on psychological home found a positive relationship with well-being and resilience in general populations and migrants. Studying psychological home in migrants may provide important tools to buffer various stresses associated with migration.

Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein.

Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively express the high affinity IL-2Rα subunit. However, even low dose IL-2, signaling through the IL2-Rβ/γ complex, may lead to the activation of proinflammatory, non-Treg T cells, so improving specificity toward Tregs may be desirable.

Older Adults and Clutter: Age Differences in Clutter Impact, Psychological Home, and Subjective Well-Being.

Previous research found mixed results for clutter's impact on individuals' sense of home and subjective well-being in a variety of samples. In this retrospective cross-sectional study, archival data were utilized to examine the relationship between clutter, psychological home, and subjective well-being across two age categories, specifically older adults aged ≥65 ( = 225), and younger adults aged ≤64 ( = 225). Three moderation analyses used age categories as a moderator exploring the relationship between (a) clutter predicting psychological home, (b) psychological home predicting subjective well-being, and (c) clutter predicting subjective well-being.

Unaccompanied migrant minors in Europe and U.S.: A review of psychological perspective and care challenges.

Unaccompanied migrant minors are youth under the age of 18 who migrate alone, traveling separately from both parents. These youth may be asylum seekers, recognized refugees, or other externally displaced persons. Unaccompanied migrant minors have become an increasingly prevalent global issue.

Online and Academic Procrastination in Students With Learning Disabilities: The Impact of Academic Stress and Self-Efficacy.

The steady growth in the number of college students with learning disabilities (LD) increases the need to investigate their unique characteristics and behaviors in academia. The present study examined the differences in academic and online procrastination, academic stress, and academic self-efficacy between college students with and without LD. In addition, the relationship between these variables was examined.

Time is on My Side-or Is It? Assessing How Perceived Control of Time and Procrastination Influence Emotional Exhaustion on the Job.

The job demands-control model (JDC) postulates that an increased control over work resources mitigates or "buffers" the positive association between job stressors and strainers. However, the inconclusive validation of the buffering hypothesis across multiple studies suggests the need for fresh approaches, both conceptual and methodological. We integrated aspects of the JDC framework and time management process models to construct a model that tested both the direct and indirect effects of the perceived control of time (PCT) on emotional exhaustion arising from workload demands.

Examining Sense of Community among Hispanic Catholic Parishes by Economic Status, Location-Site, and Family Size.

In the present study, Roman Catholic deacons at one of the 216 Hispanic parishes across the U.S. reported on their parish sense of community (P-SOC), using the SCI-2, within the congregation.

Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis.

T cells reacting to self-components can promote tissue damage when escaping tolerogenic control mechanisms which may result in autoimmune disease. The current treatments for these disorders are not antigen (Ag) specific and can compromise host immunity through chronic suppression. We have previously demonstrated that co-administration of encapsulated or free Ag with tolerogenic nanoparticles (tNPs) comprised of biodegradable polymers that encapsulate rapamycin are capable of inhibiting Ag-specific transgenic T cell proliferation and inducing Ag-specific regulatory T cells (Tregs).

Male and Female Ministers: Comparing Roman Catholic and Methodist Deacons on Personality Structure, Religious Beliefs, and Leadership Styles.

Christian deacons (50 Roman Catholic; 50 Methodist) self-reported their personality, religiosity, and leadership attributes, plus social desirability tendencies. There were no significant correlates between social desirability and any of these self-reported variables. Results also found no significant differences across Christian denominations on personality dimensions, religious and spirituality beliefs, or leadership styles.

Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles.

The development of antidrug antibodies (ADAs) is a common cause for the failure of biotherapeutic treatments and adverse hypersensitivity reactions. Here we demonstrate that poly(lactic-co-glycolic acid) (PLGA) nanoparticles carrying rapamycin, but not free rapamycin, are capable of inducing durable immunological tolerance to co-administered proteins that is characterized by the induction of tolerogenic dendritic cells, an increase in regulatory T cells, a reduction in B cell activation and germinal centre formation, and the inhibition of antigen-specific hypersensitivity reactions. Intravenous co-administration of tolerogenic nanoparticles with pegylated uricase inhibited the formation of ADAs in mice and non-human primates and normalized serum uric acid levels in uricase-deficient mice.

An Investigation of Hope and Context.

One of the tenets of community psychology is examining psychological phenomena in context, and our studies explored the relationship between hope and context among individuals in recovery for substance use disorders. Study 1 involved 595 participants who resided in 90 recovery homes. We found that context, as house effects, was salient in residents' perceptions of hope, suggesting that the context of recovery homes-- their configurations and dynamics-- may play a role in an individual's future perspective.

Substance abuse relapse in Oxford House recovery homes: A survival analysis evaluation.

Background: This study used survival analysis to examine risk factors for substance abuse relapse among residents in Oxford Houses (OH), a national network of self-run, self-financed aftercare homes for individuals recovering from substance use disorders.

Methods: Participants who entered OH within 60 days of a 1-year longitudinal study (N = 268) were selected from of a nationally representative US sample. Discrete-time survival analysis compared baseline risk of relapse with 4 hypothesized survival models that included time-invariant and time-varying factors across 3 subsequent time periods.

Hope and Abstinence Self-Efficacy: Positive Predictors of Negative Affect in Substance Abuse Recovery.

Goal-oriented thinking, including hope and self-efficacy, might play a constructive and integral role in the substance abuse recovery process, although such an effect may differ by race. The current study investigated hope and self-efficacy, specifically abstinence self-efficacy, as predictors of negative affect (i.e.

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance.

Current treatments to control pathological or unwanted immune responses often use broadly immunosuppressive drugs. New approaches to induce antigen-specific immunological tolerance that control both cellular and humoral immune responses are desirable. Here we describe the use of synthetic, biodegradable nanoparticles carrying either protein or peptide antigens and a tolerogenic immunomodulator, rapamycin, to induce durable and antigen-specific immune tolerance, even in the presence of potent Toll-like receptor agonists.

RECIPROCAL RESPONSIBILITY AND SOCIAL SUPPORT AMONG WOMEN IN SUBSTANCE USE RECOVERY.

This study sought to identify individual- and house-level predictors of women's employment, education, and retention in self-run recovery homes. Data from a national study of 292 women in Oxford House, an international organization of recovery homes grounded on self-help/mutual aid and 12-step principles were analyzed. Results indicated that the house's Reciprocal Responsibility predicted number of days of paid work.

Social anxiety and communal living: The influence of social anxiety on men and women in substance abuse recovery homes.

Research has demonstrated high rates of co-occurrence among anxiety and substance use disorders. However, few studies have specifically examined the relationship between substance use and social anxiety among individuals who are in substance abuse recovery. The present study examined social anxiety as a predictor of substance use among a sample randomized to a sober-living home versus usual aftercare.

Vocational Training and Employment Attainment among Substance Abuse Recovering Individuals within a Communal Living Environment.

Purpose: The present study explored the effects of length of stay in an Oxford House (a sober living environment) with the number of days attended school/vocational training and days worked in the past 90 days with 292 women and 604 men.

Design/methodology/approach: This paper presents quantitative data.

Findings: Results indicated that number of days residing in these recovery homes was related to number of days attending school/vocational training and days worked.

Comorbid mental health and substance abuse issues among individuals in recovery homes: Prospective environmental mediators.

Individuals with comorbid internalizing psychological symptoms and substance abuse issues often have more negative outcomes and evidence a relative disparity in treatment gains compared to those with only substance abuse issues. The present study examined social mechanisms over time for individuals living in self-governed recovery homes (Oxford Houses) such as 12-step group activities and social support, which likely influence both abstinence and psychological outcomes. Participants ( = 567) from a national United States sample of Oxford Houses completed baseline and multiple follow-up self-report assessments over a one-year period.

Person-environment interactions among residents of Oxford Houses.

The continued struggle of addiction recovery support systems suggest that the paradigm of this field needs to continue its evolution, which has increasingly emphasized environments. Field Theory suggests that the products of individual and environmental characteristics be considered rather than a summation of the two. This study examined such interactions in , a network of democratic, and self-governed addiction recovery homes.