Biochemical alterations in partial bladder outlet obstruction in mice: up-regulation of the mitogen activated protein kinase pathway.

Purpose: We evaluated the effect of partial bladder outlet obstruction on bladder weight, protein synthesis, mitotic markers and the mitogen activated protein kinase pathway in a mouse model.

Materials And Methods: Mice were divided into 3 groups, including control, sham treated and partially obstructed. Bladders were harvested from the mice in the partially obstructed group 12, 24, 48, 72 and 168 hours after surgical partial outlet obstruction, respectively.

Gene therapy for erectile dysfunction.

Erectile dysfunction is a disease that affects half of American men aged over 50 years. Many men respond to oral phosphodiesterase inhibitors but many do not. For this reason, many researchers are focusing their efforts on developing novel gene therapies for the treatment of erectile dysfunction.

Penile rehabilitation after radical prostatectomy: important therapy or wishful thinking?

On the basis of data accumulated thus far, it is reasonable to discuss the implementation of a "penile rehabilitation" program with patients undergoing radical prostatectomy. Central to discussions of penile rehabilitation after radical prostatectomy is evidence demonstrating significant fibrotic changes in the corpus cavernosum that occur postoperatively. Several studies have been published evaluating the efficacy of various pro-erectogenic agents.

Gender Differences among Hispanics and Caucasians in symptomatic presentation of kidney and ureteral stones.

Purpose: We determined gender differences in the symptomatic presentation of kidney and ureteral stones among the Hispanic population and compared it with presentation in the Caucasian population.

Patients And Methods: A retrospective chart review was performed on 443 patients seen in our Emergency Department or Urgent Care Center for symptomatic kidney or ureteral stones over a 5-year period. Demographic information was obtained, including sex, race, age, location of stone, stone size, and type of urologic intervention.