Suppression of lysyl oxidase gene expression by methylation in pelvic organ prolapse.

Introduction And Hypothesis: We measured promoter methylation in the LOX gene in women with pelvic organ prolapse and in women without prolapse.

Methods: Genomic DNA was isolated from the uterosacral ligaments of eight women with prolapse and eight women without prolapse as controls. Genomic DNA was digested with BamHI and underwent sodium bisulfite modification.