Publications by authors named "Joseph D Takacs"
Human mesenchymal stem/stromal cells (hMSCs) have been investigated and proven to be a well-tolerated, safe therapy for a variety of indications, as shown by over 900 registered hMSC-based clinical trials. To meet the commercial demand for clinical manufacturing of hMSCs, production requires a scale that can achieve a lot size of ~100B cells, which requires innovative manufacturing technologies such as 3D bioreactors. A robust suspension bioreactor process that can be scaled-up to the relevant scale is therefore crucial.
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- Bimodal stimulation of the spinal trigeminal nucleus and tone frequencies was shown to modulate both neural responses and spontaneous firing rates in the primary auditory cortex (A1) of guinea pigs, indicating potential treatment effects for tinnitus.
- Long-term effects (up to 2 hours) of the bimodal stimulation were observed, with different pairing intervals resulting in varying degrees of neural enhancement or suppression, influenced by prior noise exposure.
- The study found that noise-damaged brains exhibited altered neural synchrony and processing of sound information, which was further affected by the bimodal stimulation, suggesting potential therapeutic implications for auditory processing in noise-exposed individuals.