Urinary bladder leiomyoma associated with pulmonary lymphangioleiomyomatosis.

Leiomyomas account for less than 0.43% of all bladder tumors. To date only about 250 cases have been reported in the literature.

Isolated prostate cancer recurrence presenting as pelvic mass nine years after radical retropubic prostatectomy.

Pelvic seeding from radical retropubic prostatectomy for adenocarcinoma of the prostate is uncommon. We describe a patient who presented with a prostate-specific antigen recurrence and was found to have a solitary metastasis adjacent to his pubic bone 9 years after radical prostatectomy. Computed tomography scanning followed by surgery documented the pelvic recurrence.

Simple perineal prostatectomy: lessons learned from a modern series.

Purpose: Experience with simple perineal prostatectomy has not been well described in the recent literature. We describe our operative technique and compare objective demographic, preoperative, intraoperative and postoperative parameters in patients undergoing open prostatectomy for benign prostatic hyperplasia via 3 routes, namely perineal, retropubic, and suprapubic.

Materials And Methods: We retrospectively reviewed all cases of open prostatectomy at Veterans Affairs Medical Center, San Diego between August 2001 and September 2002.

Urology practice patterns after residency training in radical perineal prostatectomy.

Objectives: To assess the impact of residency training in radical perineal prostatectomy (RPP) on subsequent use of RPP in urology practice.

Methods: Urologists who completed residency training at Tulane University and the University of California, San Diego, Medical Center from 1977 to 1999 were surveyed by anonymous questionnaire for their practice demographics, operative experience in RPP during residency, the role of RPP in their current practice, and the reasons they do or do not perform RPP.

Results: Of 91 former residents, 61 (67%) responded.

Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells.

Telomerase reverse transcriptase (TRT) is a tumor-associated antigen expressed in the vast majority of human tumors and is presently one of the most promising target candidates for a therapeutic cancer vaccine. TRT is also expressed at low level in selected tissues and should be considered a self antigen. In the present study we sought to develop cytotoxic T lymphocytes (CTL) responses directed against human (h)TRT peptides with low relative affinity for which the available repertoire is to be preferentially spared from tolerance.

Chemotherapy Programs of the National Prostatic Cancer Project (NPCP).

Results of the first nationally randomized trial of the National Prostatic Cancer Project revealed a demonstrable advantage for chemotherapy in the management of advanced disease (Stage D in relapse from endocrine therapy). Both cyclophosphamide and 5-Fluorouracil showed improved activity over standard therapy. A second trial for patients previously irradiated, with less tolerance to myelosuppressive agents, revealed an advantage for estramustine phosphate and streptozotocin over standard therapy.