pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.

Signal transduction proteins containing a pLxIS motif induce interferon (IFN) responses central to antiviral immunity. Apart from their established roles in activating the IFN regulator factor (IRF) transcription factors, the existence of additional pathways and functions associated with the pLxIS motif is unknown. Using a synthetic biology-based platform, we identified two orphan pLxIS-containing proteins that stimulate IFN responses independent of all known pattern-recognition receptor pathways.

A mixed-methods evaluation of college student and provider perspectives on a smartphone application for help-seeking after violence.

To elicit feedback on the acceptability, usability, and dissemination options for the bMOREsafe smartphone application (app). Forty-nine students and six service-providers provided feedback on the bMOREsafe app between April 2015 and March 2016. Students responded to an anonymous online survey and providers participated in semi-structured interviews.

A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury.

Objectives: Administration of eicosapentaenoic acid and docosahexanoic acid, omega-3 fatty acids in fish oil, has been associated with improved patient outcomes in acute lung injury when studied in a commercial enteral formula. However, fish oil has not been tested independently in acute lung injury. We therefore sought to determine whether enteral fish oil alone would reduce pulmonary and systemic inflammation in patients with acute lung injury.