Catalytic Conversion of Alkenes on Acidic Zeolites: Automated Generation of Reaction Mechanisms and Lumping Technique.

Acid-catalyzed hydrocarbon transformations are essential for industrial processes, including oligomerization, cracking, alkylation, and aromatization. However, these chemistries are extremely complex, and computational (automatic) reaction network generation is required to capture these intricacies. The approach relies on the concept that underlying mechanisms for the transformations can be described by a limited number of reaction families applied to various species, with both gaseous and protonated intermediate species tracked.

Vision-related quality of life and dependency in French keratoconus patients: Impact study.

Purpose: To assess the quality of life in French keratoconus patients.

Setting: Fifty-seven Keratoconus National Reference Centers across France.

Design: Prospective case series.

Recurrent herpetic keratitis despite antiviral prophylaxis: A virological and pharmacological study.

Recurrent herpes simplex keratitis (HSK) is a leading infectious cause of blindness in industrialized countries. Antiviral prophylaxis (AVP) may fail to prevent recurrence of HSK due to viral resistance, inadequate dosing, or poor patient compliance. In this prospective multicenter study, we enrolled immunocompetent patients with recurrent HSK despite AVP.

Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery.

Background/aims: To compare the efficacy and safety of intracameral (IC) administration at the beginning of cataract surgery, of Mydrane, a standardised ophthalmic combination of tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%, to a standard topical regimen.

Potential of FTIR spectroscopy for analysis of tears for diagnosis purposes.

It has been widely reported that the tear film, which is crucially important as a protective barrier of the eye, undergoes biochemical changes as a result of a wide range of ocular pathology. This tends to suggest the possibility of early detection of ocular diseases on the basis of biochemical analysis of tears. However, studies of tears by conventional methods of biomolecular and biochemical analysis are often limited by methodological difficulties.

Patient-Reported Difference following Implantation of a Blue Light-Filtering Aspheric Intraocular Lens and a UV-Filtering Aspheric Intraocular Lens.

We report on a series of 6 patients who experienced yellow vision after uncomplicated cataract surgery in their second eye. In the first eye, an aspheric blue-light filtering intraocular lens (IOL) was implanted, followed by the implantation of a 1-Piece aspheric IOL in the second eye. The time between the surgeries ranged from 12 months to 3 years.

Prospective masked comparison of intraoperative floppy iris syndrome severity with tamsulosin versus alfuzosin.

Objective: To determine whether severe intraoperative floppy iris syndrome (IFIS) is more or equally likely with tamsulosin or alfuzosin.

Design: Prospective, masked, multicenter, cross-sectional study.

Participants And Controls: Consecutive patients taking systemic tamsulosin or alfuzosin and scheduled for routine cataract surgery (case group) and patients with no history of systemic α1-antagonists scheduled for routine cataract surgery (control group).

Glistening in glaucomatous eyes: visual performances and risk factors.

Purpose: To analyse risk factors and visual performances of glaucomatous eyes with glistening in the intra-ocular lens (IOL).

Methods: Prospective study performed between November 2010 and April 2011 and involving 67 consecutive glaucomatous eyes (47 patients), who previously had a phacoemulsification with a hydrophobic acrylic IOL implanted in the capsular bag. Glistening was classified in three groups of severity grade: G0 (<50 microvacuoles per mm(2) ), G1 (50-150 microvacuoles per mm(2) ), and G2 (>150 microvacuoles per mm(2) ).

Detection of subclinical keratoconus using an automated decision tree classification.

Purpose: To develop a method for automatizing the detection of subclinical keratoconus based on a tree classification.

Design: Retrospective case-control study.

Methods: setting: University Hospital of Bordeaux.

Dry eye disease in French elderly subjects: the Alienor Study.

Purpose:   To describe dry eye disease in French elderly subjects.

Methods:   The Alienor Study is a population-based study on age-related eye disease in 963 residents of Bordeaux (France), aged 73 years or more. Self-reported dry eye disease and use of artificial tears were documented through face-to-face interview.

Is there a link between open-angle glaucoma and dementia? The Three-City-Alienor cohort.

Objective: Previous research has suggested an association between dementia and glaucoma through common risk factors or mechanisms. Our aim was to evaluate the longitudinal relationship between open-angle glaucoma (OAG) and incident dementia.

Methods: The Three-City-Bordeaux-Alienor study is a population-based cohort of 812 participants with a 3-year follow-up period.

Influence of the reference surface shape for discriminating between normal corneas, subclinical keratoconus, and keratoconus.

Purpose: To compare the discriminating ability of corneal elevation generated by a dual Scheimpflug analyzer calculated with different reference surfaces for distinguishing normal corneas from those with keratoconus and subclinical keratoconus.

Methods: A total of 391 eyes of 208 patients were prospectively enrolled in the study and divided into three groups: 167 eyes of 113 patients with keratoconus, 47 contralateral topographically normal eyes of patients with clinically evident keratoconus in the fellow eye, and 177 eyes of 95 refractive surgery candidates with normal corneas. All eyes were measured with a dual Scheimpflug analyzer (GALILEI Analyzer; Ziemer Ophthalmic Systems AG, Port, Switzerland).

High concentrations of plasma n3 fatty acids are associated with decreased risk for late age-related macular degeneration.

High dietary intakes of n3 (ω3) polyunsaturated fatty acids (PUFA) and fish have been consistently associated with a decreased risk for age-related macular degeneration (AMD). We assessed the associations of late AMD with plasma n3 PUFA, a nutritional biomarker of n3 PUFA status. The Antioxydants Lipides Essentiels Nutrition et Maladies Occulaires (Alienor) Study is a prospective, population-based study on nutrition and age-related eye diseases performed in 963 residents of Bordeaux (France) aged ≥73 y.

Long-term blood pressure and age-related macular degeneration: the ALIENOR study.

Purpose: To explore the association of AMD with long-term average blood pressure (BP) parameters, including pulse pressure (PP).

Methods: The ALIENOR study is a population-based study on age-related eye diseases in 963 residents of Bordeaux, France, aged 73 years or older. AMD was graded from nonmydriatic color retinal photographs, in three exclusive stages: no AMD (1015 eyes), large soft distinct drusen and/or large soft indistinct drusen and/or reticular drusen and/or pigmentary abnormalities (early AMD, 276 eyes), and late AMD (66 eyes).

Corneal confocal microscopy following conventional, transepithelial, and accelerated corneal collagen cross-linking procedures for keratoconus.

Purpose: To compare early corneal healing following conventional, transepithelial, and accelerated corneal collagen cross-linking (CXL) protocols.

Methods: Twenty-four patients with progressive keratoconus were divided into three groups to receive conventional, transepithelial, or accelerated CXL. In vivo corneal confocal microscopy was performed on each patient preoperatively and at 1, 3, and 6 months postoperatively.

Comparison of corneal thickness and biomechanical properties between North African and French patients.

Purpose: To determine whether corneal thickness and rigidity vary between French and North African refractive surgery candidates.

Setting: Three clinics in North Africa and 1 hospital in France.

Design: Cross-sectional study.

Comparison of corneal thickness and curvature in myopic and keratoconic eyes of patients from French Caribbean Isles and continental France.

Purpose: To evaluate the corneal thickness and curvature of myopic and patients with keratoconus from two countries.

Methods: This cross-sectional study was conducted at Cabinet Opale, Fort de France, French West Indies and University Hospital of Bordeaux, France. Corneal thickness and curvature were assessed in 170 keratoconic eyes of 89 residents of the French Caribbean Islands (FCI) and 159 keratoconic eyes of 91 residents of the Aquitaine region of southwest France.

Severe endothelial cell loss with anterior chamber phakic intraocular lenses.

Unlabelled: We report the case of a highly myopic patient who developed severe bilateral endothelial cell loss following implantation of 2 angle-supported anterior chamber pIOL models, the Acrysof Cachet and the GBR (currently off the market).

Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

Incidence of glistenings with the latest generation of yellow-tinted hydrophobic acrylic intraocular lenses.

Purpose: To evaluate the incidence of glistenings in a large series of consecutive eyes with a blue light-filtering hydrophobic acrylic intraocular lens (IOL) and the relationship with parameters such as age, sex, follow-up length, and corrected distance visual acuity (CDVA).

Setting: Service d'Ophtalmologie, Centre Hospitalier et Universitaire Bordeaux, Bordeaux, France.

Design: Cross-sectional study.

Comparison of front-surface corneal topography and Bowman membrane specular topography in keratoconus.

Purpose: To define the contribution of the corneal epithelium in corneal topography in keratoconus and discuss the implications regarding combined topography-guided photorefractive keratectomy and corneal collagen crosslinking (CXL).

Setting: French National Reference Center for Keratoconus, Bordeaux, France.

Design: Case series.

Refractive and topographic stability of Intacs in eyes with progressive keratoconus: five-year follow-up.

Purpose: To evaluate the long-term rate of progression of keratoconus in eyes implanted with Intacs (Addition Technology Inc) at 5-year follow-up.

Methods: Data of 105 eyes from 85 patients who had undergone consecutive Intacs implantation between January 2001 and December 2005 were studied retrospectively for progression of keratoconus. Progression of keratoconus was defined as an increase in steep keratometry (K) of ≥ 1.

Scalability and severity of keratoconus in children.

Purpose: To assess the severity of keratoconus at diagnosis and its scalability over a period of 2 years in children compared to adults.

Design: A retrospective monocentric study was conducted in the National Reference Center for Keratoconus, Bordeaux (France), between October 1997 and November 2010.

Methods: In total, 216 patients were studied, comprising 49 patients (22.

Outcomes of deep anterior lamellar keratoplasty for keratoconus: learning curve and advantages of the big bubble technique.

Purpose: To evaluate retrospectively the outcomes of a case series of deep anterior lamellar keratoplasties by air dissection (DALK-AD) using the big bubble (BB) technique, in the surgical treatment of keratoconus (KC).

Methods: Forty-four consecutive keratoplasties of 42 patients for KC were performed at the French National Reference Center for KC from January 2008 to June 2010 by the same surgeon with the aim of systematically performing DALK-AD with the BB technique. The outcomes of the DALK-AD not converted to penetrating keratoplasty were analyzed, and a learning curve was established to successfully achieve the DALK-AD using the BB technique.

Nutritional, lifestyle and environmental factors in ocular hypertension and primary open-angle glaucoma: an exploratory case-control study.

Purpose: To evaluate known and potential risk factors, including nutritional, lifestyle and environmental factors, differentiating patients with high-tension primary open-angle glaucoma (POAG) from control subjects with ocular hypertension (OHT).

Methods: In 2006-2007, 111 French ophthalmologists prospectively enrolled 339 cases of POAG and 339 age-matched controls with OHT. After a clinical examination with assessment of ocular risk factors, the ophthalmologist filled, during face-to-face interview, a detailed questionnaire developed by nutritionists and epidemiologist on lifestyle and environmental risk factors, including socio-demographic variables, dietary habits related to omega-3 fatty acids intake, smoking and alcohol drinking and professional exposure to pesticides and other chemicals.