Publications by authors named "Joseph Chipanga"
Changes in peripheral quantitative computed tomography measured bone density, size, and strength in Zimbabwean children with and without HIV over one year: a cohort study.
J Bone Miner Res
November 2024
Article Synopsis
- Understanding bone growth in adolescents with HIV could help improve their skeletal health and decrease fracture risk later in life.
- The study compared bone mineral density and strength between children with HIV on antiretroviral therapy and those without HIV, revealing that children with HIV generally had lower bone measurements but similar increases over time.
- Notably, height-for-age scores were found to influence how HIV affected bone growth, impacting females more significantly in terms of bone density and strength changes.
Article Synopsis
- The study explored the links between HIV, frailty, and health-related quality of life in adults aged 40 and older in Zimbabwe, using various assessments to define and measure frailty.
- Of the 1,034 participants, 21.6% were living with HIV, with most knowing their status and receiving antiretroviral therapy, yet HIV status itself was not directly linked to increased frailty.
- However, longer duration of living with HIV increased the odds of frailty, while longer use of ART reduced those odds, suggesting that early initiation of ART may help decrease future frailty risk.
Objectives: To determine how muscle strength, power, mass, and density (i.e. quality) differ between children living with HIV (CWH) and those uninfected, and whether antiretroviral therapy (ART) regime is associated with muscle quality.
View Article and Find Full Text PDFHIV infection has multi-system adverse effects in children, including on the growing skeleton. We aimed to determine the association between chronic HIV infection and bone architecture (density, size, strength) in peripubertal children. We conducted a cross-sectional study of children aged 8 to 16 years with HIV (CWH) on antiretroviral therapy (ART) and children without HIV (CWOH) recruited from schools and frequency-matched for age strata and sex.
View Article and Find Full Text PDFEffect of HIV infection on growth and bone density in peripubertal children in the era of antiretroviral therapy: a cross-sectional study in Zimbabwe.
Lancet Child Adolesc Health
August 2021
Background: Faltered linear growth and pubertal delay, which are both common in children with HIV in sub-Saharan Africa, might affect adolescent bone accrual and future fragility fracture risk. We investigated the association of HIV with bone density adjusted for skeletal size in peripubertal children in Zimbabwe.
Methods: We did a cross-sectional study of baseline data from the IMVASK cohort, which enrolled children aged 8-16 years with HIV who had been taking antiretroviral therapy (ART) for at least 2 years, and children of the same age without HIV.