Publications by authors named "Joseph Cerra"
Article Synopsis
- Comparative genomics of predatory and non-predatory bacteria reveals significant differences in their genomes, aiding the understanding of their ecology and potential therapeutic uses against drug-resistant infections.
- Analysis of 18 obligate predatory bacteria and 15 non-predatory bacteria highlighted at least five distinct species and recent reclassifications, showcasing lineage-specific gene clusters related to predatory functions.
- Key findings include a focus on enzymes involved in peptidoglycan metabolism unique to predatory bacteria, suggesting evolutionary adaptations for their predatory lifestyle, which may be targeted for further functional studies.
Immune Cell Deconvolution methods utilizing gene expression profiling to quantify immune cells in tissues and blood are an appealing alternative to flow cytometry. Our objective was to investigate the applicability of deconvolution approaches in clinical trial settings to better investigate the mode of action of drugs for autoimmune diseases. Popular deconvolution methods CIBERSORT and xCell were validated using gene expression from the publicly available GSE93777 dataset that has comprehensive matching flow cytometry.
View Article and Find Full Text PDFWe report here the complete genome sequence of sp. strain NC02, isolated from soil in eastern Massachusetts. We assembled PacBio reads into a single closed contig with 132× mean coverage and then polished this contig using Illumina MiSeq reads, yielding a 6,890,566-bp sequence with 61.
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