Exploring Perceptions and Treatment-Seeking Behaviors for Viral Hepatitis Among the Ethnic Irula Tribe in Tamil Nadu, India: A Qualitative Study on Health Disparities.

Objectives: Qualitative research was undertaken to determine the perceptions and treatment-seeking behaviors of the Irula tribal populations in Tamil Nadu, India, and to explore the depth, diversity, and complexity of viral hepatitis.

Methods: An in-depth interview (IDI) was conducted among the eligible respondents. A purposive sampling technique was used to obtain the study subjects.

Evaluating oral health status in elderly Irula tribes of Tamil Nadu by using the Geriatric Oral Health Assessment Index.

Introduction: Oral diseases are a significant global health issue, with over 3.5 billion cases worldwide. Caries and periodontitis are primary contributors to tooth loss, which not only incurs significant rehabilitation costs but also profoundly affects overall well-being.

Enhancing Intelligent Shoes with Gait Analysis: A Review on the Spatiotemporal Estimation Techniques.

The continuous, automated monitoring of sensor-based data for walking capacity and mobility has expanded gait analysis applications beyond controlled laboratory settings to real-world, everyday environments facilitated by the development of portable, cost-efficient wearable sensors. In particular, the integration of Inertial Measurement Units (IMUs) into smart shoes has proven effective for capturing detailed foot movements and spatiotemporal gait characteristics. While IMUs enable accurate foot trajectory estimation through the double integration of acceleration data, challenges such as drift errors necessitate robust correction techniques to ensure reliable performance.

Information Needs of State-Level Asthma Programs: Recommendations to Increase Accessibility.

Asthma is the most common pediatric chronic disease, affecting about 5 million U.S. children.

Outline of Therapeutic Potential of Different Plants Reported Against Psoriasis via In Vitro, Pre-Clinical or Clinical Studies.

Psoriasis is a noncontagious, autoimmune chronic inflammatory disease with an unknown root cause. It is classified as a multifactorial and chronic skin disorder that also affects the immune system and is genetic. Environmental factors such as stress, infections, and injuries all play an important role in the disease's development.

Neutrophil-to-Lymphocyte Ratio Differentiates Infections from Sterile Inflammation in First Week of Acute Pancreatitis.

Background: Differentiating infections from sterile inflammation is crucial in early AP management.

Aim: This study aimed to assess the capability of Neutrophil-to-Lymphocyte Ratio (NLR) and procalcitonin to differentiate between sterile inflammation and infections in the first week of AP and to analyze the source, microbiological profile, and impact of infections in AP.

Methods: Consecutive patients presenting within 5 days of symptom onset were included.

Development and implementation of a 3d-HDR brachytherapy program for cervical cancer in a sub-Saharan African centre.

Background: Cervical cancer is the second most common cancer among women in Nigeria where, the gap between need for, and access to, radiation therapy including brachytherapy is significant. This report documents the implementation of the first three-dimensional high-dose-rate (3D-HDR) brachytherapy service for cervical cancer in Nigeria.

Purpose: This report details the steps taken to implement the 3D-HDR brachytherapy program, the challenges faced, and the adaptive strategies employed to overcome them.

A pilot evaluation of the diagnostic accuracy of ChatGPT-3.5 for multiple sclerosis from case reports.

The limitation of artificial intelligence (AI) large language models to diagnose diseases from the perspective of patient safety remains underexplored and potential challenges, such as diagnostic errors and legal challenges, need to be addressed. To demonstrate the limitations of AI, we used ChatGPT-3.5 developed by OpenAI, as a tool for medical diagnosis using text-based case reports of multiple sclerosis (MS), which was selected as a prototypic disease.

Safety of Gadopiclenol After Its First Year of Clinical Use.

Gadopiclenol is a novel, macrocyclic high-relaxivity gadolinium-based contrast agent recently approved for use in magnetic resonance imaging of the central nervous system and body organs at a dose of 0.05 mmol/kg body weight. Postmarketing surveillance of its first year of clinical use in the United States of America showed no serious adverse events (AEs) following over 882,550 administrations and a very low rate of nonserious AEs (1 case every 27,580 exposures).

Metal Nanoclusters for Interface Engineering and Improved Photovoltaic Performance in Organic Solar Cells.

Copper nanoclusters (Cu NCs), synthesized by a one-pot synthesis method, were theoretically shown to exhibit a dipole moment and cause work function modification on a surface as observed from Kelvin probe measurement. Here, Cu NCs were used as an interfacial modifier in organic solar cells (OSCs). The effective engineering of the electron transporting layer/active layer interface using Cu NCs resulted in improved photovoltaic performance in fullerene and non-fullerene based OSCs.

Prevalence of TB-related symptoms and self-reported disability among adult TB survivors.

Background: Growing evidence suggests that post-TB-related morbidity occurs often among TB survivors, but there is limited epidemiological data on the burden of symptoms and disability after successful completion of treatment. We evaluated the prevalence of TB-related symptoms, self-reported disability, and factors associated with disability among adult TB survivors who recently completed treatment in Uganda.

Methods: Between January 2022 and October 2023, we conducted a study of adults who completed treatment for drug-susceptible TB in Kampala, Uganda.

Intraclass Correlation in Cluster Randomized Controlled Trials: A Meta-Analysis of Studies on Major Depression.

Background: Though cluster randomized trials (CRTs) provide robust evidence for intervention by controlling contamination of interventions, there could be some loss of statistical efficiency. The Consolidated Standards of Reporting Trials (CONSORT) recommends reporting intraclass correlation coefficients (ICC) to understand this phenomenon, though not many studies follow this. This meta-analysis explored the compliance of CRTs in major depression for reporting ICC besides deriving the pooled ICC and pooled mean differences of intervention outcomes.

The role of excitation vector fields and all-polarisation state control in cavity magnonics.

Recently the field of cavity magnonics, a field focused on controlling the interaction between magnons and photons confined within microwave resonators, has drawn significant attention as it offers a platform for enabling advancements in quantum- and spin-based technologies. Here, we introduce excitation vector fields, whose polarisation and profile can be easily tuned in a two-port cavity setup, thus acting as an effective experimental dial to explore the coupled dynamics of cavity magnon-polaritons. Moreover, we develop theoretical models that accurately predict and reproduce the experimental results for any polarisation state and field profile within the cavity resonator.

The attenuation of doxorubicin-induced testicular toxicity with improved testicular histoarchitecture of mice by the bioactive compounds in leaves: Experimental and computational studies.

Doxorubicin, as an antibiotic causes toxicity in human tissues through the generation of oxidant species; however, (Solanaceae) is ethnopharmacologically and scientifically reported to possess antidotal activities. This study was designed to validate the antidotal potency of the plant's bioactive compounds on rats' testes following induction with doxorubicin through the evaluation of oxidative stress markers, lipid peroxidation indices, testes' histological sections, and profiling of the plant's bioactive compounds against some proteins. The collection and preparation of the plant extract, testicular toxicity induction, seminal analysis, assay of testosterone and oxidative stress markers, lipid peroxidation profiling, histomorphological studies, retrieval of catalase, superoxide dismutase, and glutathione peroxidase from PDB, GC-MS, ADME, and docking analyses followed standard protocols.

Technological barriers to providing pediatric mental and behavioral healthcare in emergency departments.

In the United States, about 5% of pediatric Emergency Department (ED) visits involve mental and behavioral health (MBH) emergencies, and EDs are often ill-equipped to provide timely, appropriate care, leading to prolonged stays and increased risks of trauma and harm for these children and their families. This study investigated technological barriers affecting safe and effective pediatric mental and behavioral healthcare in emergency departments through observational studies and semi-structured interviews with 55 medical professionals across four ED settings: pediatric MBH unit, pediatric ED, and adult ED. A total of 12 barrier themes were identified through the thematic analysis of the interviews relating to technology use that impacts the care of pediatric MBH patients.

Towards a Multi-Stakeholder process for developing responsible AI governance in consumer health.

Introduction: AI is big and moving fast into healthcare, creating opportunities and risks. However, current approaches to governance focus on high-level principles rather than tailored recommendations for specific domains like consumer health. This gap risks unintended consequences from generic guidelines misapplied across contexts and from providing answers before agreeing on the questions.

Correction: A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from (Wall.) Parker.

[This corrects the article DOI: 10.1039/D4MD00318G.].

PREDICTORS OF HIV STATUS DISCLOSURE AND CONDOM USE AMONG MOTHERS LIVING WITH HIV IN A TERTIARY HOSPITAL SOUTHEAST, NIGERIA.

Background: Non-disclosure of HIV status and poor condom use, among mothers living with HIV may pose risks of HIV transmission to their serodiscordant partners and may influence the outcome of their infants. The study was aimed at assessing predictors of HIV status disclosure, and condom use, among mothers of infants exposed to HIV attending the ART clinic in Abakaliki, Southeast Nigeria.

Materials And Methods: A hospital-based cross-sectional study that involved 246 mothers living with HIV.

Pediatric Brain Injuries are Associated With Intimate Partner Violence-Related Brain Injuries Among Women in Adulthood.

Objective: Prior studies have reported associations between childhood physical abuse and intimate partner violence (IPV). However, there has been limited literature examining the relationship between pediatric brain injuries and IPV-related brain injuries later in life. We examined the association between childhood brain injuries and brain injuries sustained from IPV in adulthood.

Enhancing Hole Transport and Autonomous Healing Properties of Supramolecular Columns in Unsymmetrical Discotics.

Designing smart autonomous healing soft materials is crucial to attaining cost-efficiency and optimal performance in organic semiconductors. In this context, we design an unsymmetrical thiophene-fused phenazine (TFP)-based discotic liquid crystal (DLC) with the goal of creating an active organic semiconductor that encompasses favorable attributes, such as polarizability, mobility, and processability. Aligned with our objective, we successfully synthesized two unsymmetrical TFP core-based DLCs by linking alkyl chains of variable lengths at the periphery through a coupling reaction.

A Simplified Mathematical Model for Cell Proliferation in a Tissue-Engineering Scaffold.

While the effects of external factors like fluid mechanical forces and scaffold geometry on tissue growth have been extensively studied, the influence of cell behavior-particularly nutrient consumption and depletion within the scaffold-has received less attention. Incorporating such factors into mathematical models allows for a more comprehensive understanding of tissue-engineering processes. This work presents a comprehensive continuum model for cell proliferation within two-dimensional tissue-engineering scaffolds.

Health risk assessment of lead, cadmium, heavy metals and metalloids in residential paint flakes from indoor wall surfaces.

Paint components pose risky metals like lead, cadmium, arsenic, and mercury that endanger occupants, mainly children and pregnant women. To assess the levels and health risks of 14 metals in paint flakes from indoor walls of residential houses in four states in South-western Nigeria. Flaked paints were collected from 144 houses where children reside.

Long-Lasting Exendin-4-Coated Gold Nanoparticles: Synthesis and In Vivo Evaluation of Hypoglycemic Activity.

Background: Gold nanoparticles (NPs) have drawn great attention in the area of biomedical research with their relatively safe and versatile properties. This study aimed to synthesize long-lasting exendin-4-coated gold NPs (EX-ABD-AFF-GoldNPs) and evaluate their anti-diabetic effects in vivo.

Methods: In the present study, EX-ABD-AFF-GoldNPs were synthesized using a simple one-step aqueous reduction method.