Publications by authors named "Joseph A Reed"
Virus recognition has been driven to the forefront of molecular recognition research due to the COVID-19 pandemic. Development of highly sensitive recognition elements, both natural and synthetic is critical to facing such a global issue. However, as viruses mutate, it is possible for their recognition to wane through changes in the target substrate, which can lead to detection avoidance and increased false negatives.
View Article and Find Full Text PDFBackground: This study aimed to describe the prevalence of type 2 diabetes and combinations of multiple chronic conditions (MCCs) that are leading causes of death (LCD) and confirm that disparities exist between groups based on race and sex.
Materials And Methods: We conducted a retrospective cohort study using 2012 Medicare claims data from beneficiaries with type 2 diabetes over the age of 65 in the state of Michigan.
Results: Female beneficiaries have type 2 diabetes and 1 or more MCCs that are LCD more often than males.
Article Synopsis
- Activation-induced deaminase (AID) can create errors in both antibody genes and non-immunoglobulin genes, potentially leading to B cell lymphoma if not repaired properly.
- The study reveals that AID also targets telomeres, and uracil-DNA glycosylase (UNG) is crucial for repairing the damage caused by AID to prevent genomic instability in B cells.
- Without UNG, the mismatch repair system can cause telomere loss, hindering B cell proliferation and decreasing the expansion of B cell clones, suggesting that AID damage at telomeres works as a safeguard against tumor development.