Publications by authors named "Joseph A Dougherty"
J Allergy Clin Immunol
December 2006
Article Synopsis
- Dendritic cells and lymphocytes are crucial for allergic asthma, but the role of CCR7 agonists CCL19 and CCL21 in this condition is not well understood.
- A study using mutant mice lacking these chemokines showed that while airway hyperreactivity remained the same, there was significantly increased airway inflammation compared to normal mice.
- The findings suggest that CCR7 deficiency leads to severe asthma symptoms without enhancing airway hyperreactivity, indicating a potential therapeutic target for improving allergic asthma treatment.
