Publications by authors named "Josep Ma Sune-Negre"
Article Synopsis
- - The Blood-Brain Barrier (BBB) makes it difficult for drugs to reach the central nervous system, but nanotechnology, particularly lipid nanoparticles with surface modifications, shows promise in improving drug delivery.
- - A systematic review analyzed 2041 articles, identifying 80 relevant studies which highlighted that peptides are the most common modification for enhancing BBB permeability, followed by mixed strategies and proteins.
- - Key findings indicated that factors like nanoparticle type, size (preferably under 150 nm), and functionalization strategy significantly influence drug delivery efficiency, underscoring the need for standardized testing methods to guide future research in this area.
Unlabelled: Risk analysis tools can be applied in the early stages of the research, development, and innovation of pharmaceutical drugs. We used a risk ranking and filtering method to optimize time resources in internal audits of project development documents in order to ensure traceability in a university pilot plant. Data gathered during audits undertaken over a 14 month period were classified according to risk factors at several levels.
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