Publications by authors named "Josep M Sopena"
The link between literacy difficulties and brain alterations has been described in depth. Resting-state fMRI (rs-fMRI) has been successfully applied to the study of intrinsic functional connectivity (iFc) both in dyslexia and typically developing children. Most related studies have focused on the stages from late childhood into adulthood using a seed to voxel approach.
View Article and Find Full Text PDFPurpose: To present fundamental anatomical aspects and technical skills necessary to urethra and urinary bladder catheterization in female mice and rats.
Methods: Urethral and bladder catheterization has been widely utilized for carcinogenesis and cancer research and still remains very useful in several applications: from toxicological purposes as well as inflammatory and infectious conditions to functional aspects as bladder dynamics and vesicoureteral reflux, among many others.
Results: Animal models are in the center of translational research and those involving rodents are the most important nowadays due to several advantages including human reproducibility, easy handling and low cost.
Article Synopsis
- Urethral cancer is rare, making up less than 1% of genitourinary tumors, predominantly affecting women in their 60s and 70s, with squamous cell carcinoma being the most common type.
- Symptoms often resemble benign conditions, leading to delays in diagnosis that can extend up to three years, resulting in most cases being diagnosed at an advanced stage with a poor prognosis.
- Treatment approaches are not standardized due to the cancer's rarity but typically involve a combination of surgery, chemotherapy, and radiotherapy; in one case, an 80-year-old patient with advanced cancer could not undergo surgery and showed rapid disease progression despite receiving chemotherapy and radiotherapy.
An experimental study on two decision issues for wrapper feature selection (FS) with multilayer perceptrons and the sequential backward selection (SBS) procedure is presented. The decision issues studied are the stopping criterion and the network retraining before computing the saliency. Experimental results indicate that the increase in the computational cost associated with retraining the network with every feature temporarily removed before computing the saliency is rewarded with a significant performance improvement.
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