Background: Patients are commonly reported as being allergic to beta-lactam (BL) antibiotics. However, many patients with this reported allergy are able to receive BL treatments because they do not have true allergies. In many cases these are simply intolerances due to side effects reported as an allergy.
View Article and Find Full Text PDFBacterial endophthalmitis constitutes a medical emergency due to the possibility of leading to blindness unless treatment is administered quickly. The usual treatment seeks to cover both gram-positive and gram-negative bacteria by intravitreal injections of vancomycin and ceftazidime. In the present work, we sought to determine the physicochemical and microbiological stability of intravitreal syringes of vancomycin 10 mg/mL in order to be able to store them as long as possible to have immediate stock.
View Article and Find Full Text PDFObjective: The goal of this article is to analyze the situation of harmacokinetics and pharmacogenetics units in the pharmacy departments of Spanish hospitals, evaluate their development both in the clinical and educational areas, and draw up a map reflecting their current status. Method: A 29-item survey structured in five blocks was designed with general questions about the respondents' hospital and the clinical and educational activities carried out by their pharmacy department, in the fields of both pharmacokinetics and pharmacogenetics.
Results: Sixty-nine hospitals answered the survey.
Background: We investigated physical and chemical stability of daptomycin and vancomycin in heparin or sodium citrate lock solutions. The aim of this study was to find the optimal combination of antimicrobials and additives for lock solutions, which maximized patient safety.
Methods: Vancomycin and daptomycin were diluted with heparin or sodium citrate to achieve final concentrations of vancomycin-heparin 2.