Reelin signaling pathway genotypes and Alzheimer disease in a Spanish population.

Background: Several reports suggest that the reelin protein could play a role in Alzheimer pathophysiology. This led us to ask whether genetic variability in the reelin pathway may increase the risk of developing Alzheimer disease (AD) or mild cognitive impairment (MCI).

Methods: This was a case-control study in which neuropsychological tests were administered and peripheral blood samples taken.