[Chronic renal failure and growth hormone: effects on GH-IGF axis and leptin].

Aim: To analyze the changes in IGF-1, IGFBP-3, leptin and insulin after replacement doses of recombinant human growth hormone (rhGH) in short prepubertal children with chronic renal failure (CRF).

Patients And Methods: Eleven children (3F:8M), with mean age of 9.6 years, were treated with rhGH (0.