Publications by authors named "Josefine Lindroos"
Article Synopsis
- Increased visceral fat is linked to a higher risk of diabetes and metabolic syndrome, largely influenced by excessive glucocorticoids (GCs).
- The study identifies the gene LIM domain only 3 (LMO3) as upregulated in human obese visceral adipose tissue, particularly within adipocytes, and correlates it with another enzyme, 11β-HSD1, that activates GCs locally.
- LMO3 influences adipogenesis, where its overexpression enhances fat cell development while its silencing inhibits it, indicating LMO3's role in visceral fat accumulation due to excess glucocorticoids in humans.
Objective: T cells and level of the cytokine interferon-γ (IFN-γ) are increased in adipose tissue in obesity. Hedgehog (Hh) signaling has been shown to potently inhibit white adipocyte differentiation. In light of recent findings in neurons that IFN-γ and Hh signaling cross-talk, we examined their potential interaction in the context of adipogenesis.
View Article and Find Full Text PDFPsoriasis is a chronic inflammatory skin disease primarily driven by Th17 cells. IL-23 facilitates the differentiation and induces complete maturation of Th17 cells. Lesional psoriatic skin has increased levels of IL-23 and recent studies show that intradermal injections of IL-23 induce a psoriasis-like skin phenotype in mice.
View Article and Find Full Text PDFBackground: Heme Oxygenase-1 (HO-1) is expressed in many cancers and promotes growth and survival of neoplastic cells. Recently, HO-1 has been implicated in tumor cell invasion and metastasis. However, the molecular mechanisms underlying these biologic effects of HO-1 remain largely unknown.
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