Estimating glomerular filtration rate (GFR) in children. The average between a cystatin C- and a creatinine-based equation improves estimation of GFR in both children and adults and enables diagnosing Shrunken Pore Syndrome.

Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFR) and a creatinine-based (eGFR) equation shows at least the same diagnostic performance as GFR estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparison of eGFR and eGFR plays a pivotal role in the diagnosis of Shrunken Pore Syndrome, where low eGFR compared to eGFR has been associated with higher mortality in adults. The present study was undertaken to elucidate if this concept can also be applied in children.