Publications by authors named "Josef Vaclavik"
Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis).
Environ Toxicol Pharmacol
February 2022
Article Synopsis
- The study investigated how different doses of fluoxetine in food affect juvenile rainbow trout, focusing on their morphology, hematology, biochemistry, and oxidative stress.* -
- Significant changes were observed in the fish's immune response, with an increased neutrophil/lymphocyte ratio and decreased lymphocyte count, alongside reduced detoxifying enzyme activity in the liver and kidney.* -
- Histopathological analysis showed damage to the kidney's proximal tubules, confirming that fluoxetine has notable adverse effects on the health of rainbow trout.*
Environmental concentrations of pharmacologically active substances are increasing dramatically throughout the world, to the point where they are now considered a serious threat to the aquatic environment. This high occurrence of pharmaceutical residues in the aquatic environment is due to an increase in i) the prescription and consumption of drugs, and ii) their subsequent discharge into wastewater and its imperfect purification in wastewater treatment plants. Recent surveys have clearly shown that such substances can have serious negative effects on non-target organisms.
View Article and Find Full Text PDFThe worldwide consumption of antidepressants is raising as well as their concentrations in the aquatic environment. This increases the risk of food chain contamination and bioaccumulation in aquatic biota. The aim of this study was to describe a potential risk of sertraline as a pollutant from water environment, wherein rainbow trout (Oncorhynchus mykiss) has been chosen as the test organism, because predatory fish are on the top of the food chain in the aquatic environment.
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