[Recommendation for standardized medical care for children and adolescents with long COVID].

This current consensus paper for long COVID complements the existing AWMF S1 guidelines for long COVID with a detailed overview on the various clinical aspects of long COVID in children and adolescents. Members of 19 different pediatric societies of the DGKJ convent and collaborating societies together provide expert-based recommendations for the clinical management of long COVID based on the currently available but limited academic evidence for long COVID in children and adolescents. It contains screening questions for long COVID and suggestions for a structured, standardized pediatric medical history and diagnostic evaluation for patients with suspected long COVID.

Glucose Tolerance in Patients with Cystic Fibrosis - Results from the German Cystic Fibrosis Registry.

Background: Oral glucose tolerance (OGT) deteriorates progressively in cystic fibrosis (CF). Clinical registries provide a unique basis to study real-world data.

Patients & Methods: OGT tests (OGTTs) documented in the German CF-registry in 2016 were classified according WHO, modified by ADA: normal glucose tolerance (NGT), indeterminate glycaemia (INDET), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), IFG+IGT, diabetes mellitus (DM).

Gene therapy for cystic fibrosis lung disease: current status and future perspectives.

Cystic fibrosis (CF) is an autosomal recessive genetic disease affecting > 70,000 individuals worldwide. Despite improvements in current therapies, most patients do not survive beyond their early 30s. After cloning of the cystic fibrosis transmembrane regulator (CFTR) gene, there was considerable clinical interest in the possible therapeutic delivery of CFTR genes directly to the lung.