TdP Incidence in Methoxamine-Sensitized Rabbit Model Is Reduced With Age but Not Influenced by Hypercholesterolemia.

Metabolic syndrome is associated with hypercholesterolemia, cardiac remodeling, and increased susceptibility to ventricular arrhythmias. Effects of diet-induced hypercholesterolemia on susceptibility to torsades de pointes arrhythmias (TdP) together with potential indicators of arrhythmic risk were investigated in three experimental groups of Carlsson's rabbit model: (1) young rabbits (YC, young control, age 12-16 weeks), older rabbits (AC, adult control, age 20-24 weeks), and older age-matched cholesterol-fed rabbits (CH, cholesterol, age 20-24 weeks). TdP was induced by α-adrenergic stimulation by methoxamine and I block in 83% of YC rabbits, 18% of AC rabbits, and 21% of CH rabbits.

Original Research: Combined model of bladder detrusor smooth muscle and interstitial cells.

Although patients with lower urinary tract symptoms constitute a large and still growing population, understanding of bladder detrusor muscle physiology remains limited. Understanding the interactions between the detrusor smooth muscle cells and other bladder cell types (e.g.

Possibilities of experimental verification of the validity of urethral pressure profilometry.

Objectives: The aim is to define conditions for exact measurement of urethral pressure profile, to prepare an aparatus and fabricate an artificial urethra for testing measuring catethers. To examine it's qualities by experiment.

Methods: We designed a measuring appliance and a specialized software for measuring and evaluating.

ConSeq: the identification of functionally and structurally important residues in protein sequences.

Motivation: ConSeq is a web server for the identification of biologically important residues in protein sequences. Functionally important residues that take part, e.g.