Publications by authors named "Josef Janku"
Article Synopsis
- The study investigates how a series of diamondoids interact with cytochrome P450 enzymes, specifically the CYP2B subfamily.
- The research involved docking these diamondoids into a model of the CYP2B4 enzyme, revealing that their binding affinity correlates well with experimental inhibition data.
- The analysis suggests that the hydrophobic nature of the diamondoids and the specific structure of their binding site might make 3-IPMDIA a strong candidate for clinical applications.
Polycyclic aromatic hydrocarbons (PAH) are pollutants frequently found in soils, particularly in urban areas. From polluted soils, the PAH can be taken up into crops and the consumption of these crops can result in a human health risk. We estimated the bioconcentration factors (BCF) in the edible plant tissues for PAH using crop-specific models for leafy vegetables, root vegetables, potatoes and tree fruits.
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