Publications by authors named "Josean Cruz"
Article Synopsis
- * E1A-immortalized murine embryonic fibroblasts (MEFs) from both POLG-deficient and wild-type (WT) mice showed a pyruvate dependency, with POLG-deficient MEFs being more affected by mitochondrial inhibitors and producing higher levels of reactive oxygen species (ROS).
- * The study examined how activating AMPK with AICAR and inhibiting mTOR with rapamycin affected mitochondrial function; results indicated varying impacts on respiration and ATP levels depending on the treatment and MEF type, highlighting
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by progressive motor neuron degeneration in the brain and spinal cord leading to muscle atrophy, paralysis, and death. Mitochondrial dysfunction is a major contributor to motor neuron degeneration associated with ALS progression. Mitochondrial abnormalities have been determined in spinal cords of animal disease models and ALS patients.
View Article and Find Full Text PDFParkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein accumulation and loss of dopaminergic neurons in the substantia nigra (SN) region of the brain. Increased levels of alpha-synuclein have been shown to result in loss of mitochondrial electron transport chain complex I activity leading to increased reactive oxygen species (ROS) production. WT alpha-synuclein was stably overexpressed in human BE(2)-M17 neuroblastoma cells resulting in increased levels of an alpha-synuclein multimer, but no increase in alpha-synuclein monomer levels.
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