The study explores how different COVID-19 booster vaccinations and recovery from Omicron BA.5 infections affect the body's ability to neutralize various Omicron sublineages.
Bivalent booster recipients showed significantly better neutralization abilities against specific Omicron variants compared to monovalent booster recipients, while individuals recovered from BA.5 had similar neutralizing antibody levels to bivalent recipients.
Despite enhanced responses, there were limitations in neutralization against newer subvariants, highlighting the necessity for potentially updated vaccines to tackle these evolving strains.