Publications by authors named "Jose-Nicolas Alcala-Pedrajas"
Article Synopsis
- - The study investigates the relationship between COVID-19 and heart failure (HF), focusing on identifying risk factors for HF among hospitalized COVID-19 patients in Spain.
- - A total of 16,474 patients were analyzed, with 5.8% developing HF; significant risk factors included older age, atrial fibrillation, obesity, and peripheral vascular disease.
- - Patients who developed HF had notably higher mortality rates, increased need for intubation, and higher ICU admission rates compared to those who did not develop HF.
Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain).
BMC Geriatr
June 2022
Background: Old age is one of the most important risk factors for severe COVID-19. Few studies have analyzed changes in the clinical characteristics and prognosis of COVID-19 among older adults before the availability of vaccines. This work analyzes differences in clinical features and mortality in unvaccinated very old adults during the first and successive COVID-19 waves in Spain.
View Article and Find Full Text PDFAcetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in hospitalized COVID-19 patients. We realized an observational retrospective cohort study of 20,641 patients with COVID-19 pneumonia collected and followed-up from Mar 1st, 2020 to May 1st, 2021, from the nationwide Spanish SEMI-COVID-19 Registry.
View Article and Find Full Text PDFArticle Synopsis
- Research aimed to compare COVID-19 impacts between older adults in long-term care facilities (LTCF) and those living in the community, focusing on clinical and epidemiological differences, hospital management, and outcomes.
- Among hospitalized patients aged 75 and older, LTCF residents were found to be older, more likely to have functional dependence, comorbidities, and dementia, and had shorter symptom durations than community-dwelling peers.
- Key mortality risk factors for LTCF residents included severe functional dependence and hypoxia; however, after adjusting for other factors, their in-hospital mortality rate was lower than initially observed.
Background: The effects of cardiometabolic drugs on the prognosis of diabetic patients with COVID-19, especially very old patients, are not well known. This work was aimed to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ≥80 years with type 2 diabetes mellitus (T2DM) hospitalized for COVID-19.
Method: We conducted a nationwide, multicenter, observational study in patients ≥80 years with T2DM hospitalized for COVID-19 between March 1 and May 29, 2020.
Article Synopsis
- The study investigates different clinical presentations of COVID-19 pneumonia by analyzing 12,066 patients to identify distinct phenotypes and their prognostic significance.
- The cluster analysis revealed four clinical phenotypes, with the majority exhibiting a triad of fever, cough, and dyspnea, while specific additional symptoms varied among the clusters.
- Cluster C1, which represents the largest group, showed the highest in-hospital mortality rate (24.1%) compared to the other clusters, highlighting the importance of specific clinical features in predicting outcomes.
Background: The relationship between body mass index (BMI) and mortality in patients with established arterial disease remains controversial.
Methods: FRENA is an ongoing, observational registry of consecutive outpatients with coronary artery disease (CAD), cerebrovascular disease, or peripheral artery disease (PAD). We examined the prognostic importance of accepted BMI categories on outcome among patients in the FRENA registry.