LAM Test: A New Cognitive Marker for Early Detection in Preclinical Alzheimer's Disease.

Background: With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive to Alzheimer's disease (AD) pathology in preclinical stages.

Objective: To determine the utility of a newly developed Learning and Associative Memory face test: LAM test. This study examined the relationship between AD cerebrospinal fluid (CSF) biomarkers and performance on LAM test, and assessed its potential clinical applicability to detect subtle changes in cognitively healthy subjects at risk for AD.

Identification of hypermucoviscous Klebsiella pneumoniae K1, K2, K54 and K57 capsular serotypes by Raman spectroscopy.

Antimicrobial resistance poses a significant challenge in modern medicine, affecting public health. Klebsiella pneumoniae infections compound this issue due to their broad range of infections and the emergence of multiple antibiotic resistance mechanisms. Efficient detection of its capsular serotypes is crucial for immediate patient treatment, epidemiological tracking and outbreak containment.

Non-Contact Thermal and Acoustic Sensors with Embedded Artificial Intelligence for Point-of-Care Diagnostics.

This work involves exploring non-invasive sensor technologies for data collection and preprocessing, specifically focusing on novel thermal calibration methods and assessing low-cost infrared radiation sensors for facial temperature analysis. Additionally, it investigates innovative approaches to analyzing acoustic signals for quantifying coughing episodes. The research integrates diverse data capture technologies to analyze them collectively, considering their temporal evolution and physical attributes, aiming to extract statistically significant relationships among various variables for valuable insights.

Design and Verification of Integrated Circuitry for Real-Time Frailty Monitoring.

In this study, a new wireless electronic circuitry to analyze weight distribution was designed and incorporated into a chair to gather data related to common human postures (sitting and standing up). These common actions have a significant impact on various motor capabilities, including gait parameters, fall risk, and information on sarcopenia. The quality of these actions lacks an absolute measurement, and currently, there is no qualitative and objective metric for it.

Delocalized Electric Field Enhancement through Near-Infrared Quasi-BIC Modes in a Hollow Cuboid Metasurface.

The two main problems of dielectric metasurfaces for sensing and spectroscopy based on electromagnetic field enhancement are that resonances are mainly localized inside the resonator volume and that experimental Q-factors are very limited. To address these issues, a novel dielectric metasurface supporting delocalized modes based on quasi-bound states in the continuum (quasi-BICs) is proposed and theoretically demonstrated. The metasurface comprises a periodic array of silicon hollow nanocuboids patterned on a glass substrate.

Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions.

Photodynamic therapy (PDT) is an increasingly popular dermatological treatment not only used for life-threatening skin conditions and other tumors but also for cosmetic purposes. PDT has negligible effects on underlying functional structures, enabling tissue regeneration feasibility. PDT uses a photosensitizer (PS) and visible light to create cytotoxic reactive oxygen species, which can damage cellular organelles and trigger cell death.

Polarisation-independent ultrafast laser selective etching processing in fused silica.

In fused silica, ultrafast laser assisted etching enables high chemical etching rates (>300 μm h) by setting a light polarisation linear and perpendicular to the beam writing direction. However, for many non-planar surfaces and 3D structures, dynamic polarisation control is difficult or not yet possible to implement. In this contribution, we identify a laser inscription regime in which high etching rates are accomplished independently of the light polarisation.

Automatic classification of Candida species using Raman spectroscopy and machine learning.

One of the problems that most affect hospitals is infections by pathogenic microorganisms. Rapid identification and adequate, timely treatment can avoid fatal consequences and the development of antibiotic resistance, so it is crucial to use fast, reliable, and not too laborious techniques to obtain quick results. Raman spectroscopy has proven to be a powerful tool for molecular analysis, meeting these requirements better than traditional techniques.

Photonic Microfluidic Technologies for Phytoplankton Research.

Phytoplankton is a crucial component for the correct functioning of different ecosystems, climate regulation and carbon reduction. Being at least a quarter of the biomass of the world's vegetation, they produce approximately 50% of atmospheric O2 and remove nearly a third of the anthropogenic carbon released into the atmosphere through photosynthesis. In addition, they support directly or indirectly all the animals of the ocean and freshwater ecosystems, being the base of the food web.

A Dual-Wavelength Fiber Laser Sensor with Temperature and Strain Discrimination.

This work presents a dual-wavelength C-band erbium-doped fiber laser assisted by an artificial backscatter reflector. This fiber-based reflector, inscribed by femtosecond laser direct writing, was fabricated into a single mode fiber with a length of 32 mm. The dual-wavelength laser obtained, centered at 1527.

Comparison of Mg/Ca concentration series from Patella depressa limpet shells using CF-LIBS and LA-ICP-MS.

The elemental composition of marine mollusk shells can offer valuable information about environmental conditions experienced by a mollusk during its lifespan. Previous studies have shown significant correlations between Mg/Ca concentration ratios measured on biogenic carbonate of mollusk shells and sea surface temperature (SST). Here we propose the use of Laser-Induced Breakdown Spectroscopy (LIBS) and the validation of the Calibration-Free LIBS (CF-LIBS) approach for the rapid measurement and estimation of Mg/Ca molar concentration profiles within Patella depressa Pennant, 1777 limpet shells.

Enhanced refractometer for aqueous solutions based on perfluorinated polymer optical fibres.

The use of the new CYTOP (Cyclized Transparent Optical Polymer) fibres for the inscription of optical structures and the detection of different parameters has started to gain importance in the past decade. This work presents the design, simulation and manufacture of a CYTOP-based surrounding refractive index sensor for aqueous solutions, given its high sensitivity in the range 1.315 - 1.

Sensing Using Light: A Key Area of Sensors.

This invited featured paper offers a Doctrinal Conception of sensing using Light (SuL) as an "umbrella" in which any sensing approach using Light Sciences and Technologies can be easily included. The key requirements of a sensing system will be quickly introduced by using a bottom-up methodology. Thanks to this, it will be possible to get a general conception of a sensor using Light techniques and know some related issues, such as its main constituted parts and types.

Recent Advances in Biomedical Photonic Sensors: A Focus on Optical-Fibre-Based Sensing.

In this invited review, we provide an overview of the recent advances in biomedical photonic sensors within the last five years. This review is focused on works using optical-fibre technology, employing diverse optical fibres, sensing techniques, and configurations applied in several medical fields. We identified technical innovations and advancements with increased implementations of optical-fibre sensors, multiparameter sensors, and control systems in real applications.

Photodynamic Therapy: A Compendium of Latest Reviews.

Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources.

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review.

Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some of the main beneficial features of PDT. Despite the great potential, its application remains challenging.

Liquid level sensor based on dynamic Fabry-Perot interferometers in processed capillary fiber.

In this work, a novel optical fiber sensor capable of measuring both the liquid level and its refractive index is designed, manufactured and demonstrated through simulations and experimentally. For this, a silica capillary hollow-core fiber is used. The fiber, with a sensing length of 1.

Optical Fiber Sensors by Direct Laser Processing: A Review.

The consolidation of laser micro/nano processing technologies has led to a continuous increase in the complexity of optical fiber sensors. This new avenue offers novel possibilities for advanced sensing in a wide set of application sectors and, especially in the industrial and medical fields. In this review, the most important transducing structures carried out by laser processing in optical fiber are shown.

Estimation of surgeons' ergonomic dynamics with a structured light system during endoscopic surgery.

Background: The purpose of this study was to use motion capture to collect body posture information during simulated endoscopic sinus surgery interventions performed by both specialists and residents in standing and sitting positions and to analyze that information with the validated Rapid Upper Limb Assessment (RULA) tool, which allows calculation of a risk index of musculoskeletal overload.

Methods: Bilateral endoscopic sinus surgery was performed in 5 cadaver heads by 2 residents, and 4 practicing rhinologists. Musculoskeletal symptoms were evaluated before and after the dissection.

Comparative Experimental Study of a High-Temperature Raman-Based Distributed Optical Fiber Sensor with Different Special Fibers.

An experimental study of a high temperature distributed optical fiber sensor based on Raman Optical-Time-Domain-Reflectometry (ROTDR) (up to 450 °C) and optical fibers with different coatings (polyimide/carbon, copper, aluminum and gold) is presented. Analysis of the distributed temperature sensor (DTS) measurements determined the most appropriate optical fiber to be used in high temperature industrial environment over long periods of time. To demonstrate the feasibility of this DTS for an industrial application, an optical cable was designed with the appropriate optical fiber and it was hermetically sealed to provide the required mechanical resistance and isolate the fiber from environmental degradations.

Identification of Human Pathological Mitral Chordae Tendineae Using Polarization-sensitive Optical Coherence Tomography.

Defects of the mitral valve complex imply heart malfunction. The chordae tendineae (CTs) are tendinous strands connecting the mitral and tricuspid valve leaflets to the papillary muscles. These CTs are composed of organized, wavy collagen bundles, making them a strongly birefringent material.

Roadmap on optical sensors.

Sensors are devices or systems able to detect, measure and convert magnitudes from any domain to an electrical one. Using light as a probe for optical sensing is one of the most efficient approaches for this purpose. The history of optical sensing using some methods based on absorbance, emissive and florescence properties date back to the 16th century.

Low-cost fiber specklegram sensor for noncontact continuous patient monitoring.

Different low-cost approaches based on fiber specklegram sensors are employed to measure the physiological activity of patients lying in bed. This study is conducted over 20 volunteers to measure the movement and heart rate (HR) using two different sensor designs placed at two different bed locations. Three different processing methods are developed and tested in order to extract useful information from the measured data.

Automated Measurement of Magnesium/Calcium Ratios in Gastropod Shells Using Laser-Induced Breakdown Spectroscopy for Paleoclimatic Applications.

The chemical composition of mollusk shells offers information about environmental conditions present during the lifespan of the organism. Shells found in geological deposits and in many archeological sites can help to reconstruct past climatic conditions. For example, a correlation has been found between seawater temperature and the amount of some substituent elements (e.

Proposal of Brillouin optical frequency-domain reflectometry (BOFDR).

We demonstrate a Brillouin optical frequency-domain reflectometry (BOFDR) technique, which can measure the strain and/or temperature along an optical fiber with one-end access, by detecting the spontaneous Brillouin scattering from a sinusoidally modulated pump light. Compared to the Brillouin optical frequency-domain analysis (BOFDA), we show that BOFDR measurements are free from the distorting components related to acoustic wave modulation, thus simplifying data processing.