Publications by authors named "Jose-Maria Galvan-Roman"
Article Synopsis
- - Long-COVID (LC) is defined by lingering symptoms for over 3 months post-COVID-19 infection, potentially caused by immune system dysregulation and chronic inflammation.
- - The study identifies specific CD4 T cell subpopulations in COVID-19 recovery and reveals that certain CCR6-expressing T cells are reduced in LC patients, while others increase.
- - LC patients demonstrate lower levels of IFN-γ-secreting CD8 T cells when exposed to the SARS-CoV-2 Spike protein, highlighting the importance of CCR6 in understanding LC's underlying mechanisms.
Article Synopsis
- The study investigates the connection between SARS-CoV-2 viral load (viremia) and genetic variations (SNPs) linked to the severity of COVID-19 in a group of hospitalized patients at University Hospital La Princesa.
- Out of 340 patients analyzed, only 37.1% had positive viremia, with specific SNPs (like rs2071746 and rs78958998) associated with a higher risk of viremia, while others (like rs11052877 and rs33980500) were linked to a lower risk.
- The findings suggest that certain genetic variants contribute to differences in SARS-CoV-2 viremia among individuals, highlighting the
Objective: To study the respiratory patterns and the hemodynamic variations related to postural changes in inpatients with coronavirus disease (COVID-19).
Methods: This report is a prospective study in a cohort of inpatients admitted with COVID-19. We recruited 10 patients admitted to the hospital with moderate or severe COVID-19 who showed improvement in oxygen saturation with prone positioning.
To describe congenital and acquired heart diseases in a Spanish cohort of adults with Down syndrome (DS), which could inform potential health recommendations for this population. Cross-sectional, observational study of adults with DS evaluated consecutively at a tertiary care, outpatient center between January 1 and December 31, 2019. The study population comprised 937 patients (51.
View Article and Find Full Text PDFBackground: Interleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not been assessed in a prospective cohort. Our aim was to evaluate the relationship between SARS-CoV-2 viremia and time evolution of IL6 levels in a COVID-19 prospective cohort.
View Article and Find Full Text PDFAmong patients affected by the virus COVID-19, physicians have observed ventilation disorders. It is relevant to assess neurological involvement, including the role of diaphragmatic function. Its possible impairment could be related to the systemic inflammatory response and disease progression that both typify COVID-19 infection.
View Article and Find Full Text PDFArticle Synopsis
- COVID-19 pneumonia is a severe infectious disease that poses a significant risk, particularly to older patients with existing health issues, and the mechanisms behind it are still not fully understood.
- The study compared the profiles of specific miRNAs and cytokines in patients with COVID-19 and those with other forms of pneumonia, leading to the identification of 15 miRNAs that are altered in COVID-19.
- A subgroup of four specific miRNAs was found to effectively distinguish between COVID-19 and other pneumonia cases, while certain cytokine levels also differed significantly between mild and severe COVID-19 patients, contributing to a better understanding of the disease's underlying mechanisms.
COVID-19 has overloaded national health services worldwide. Thus, early identification of patients at risk of poor outcomes is critical. Our objective was to analyse SARS-CoV-2 RNA detection in serum as a severity biomarker in COVID-19.
View Article and Find Full Text PDFTo date, healthcare ethics committees (HEC) have been the only ethics consultation model in the hospital setting in Spain, though their usefulness for ethical conflict resolution in daily practice has been questioned. Individual clinical ethics consultation (CEC) is a complementary ethics consultation model, which has proved efficacious in real-time ethical problem-solving. Although CEC is widely used in North America, its implementation in Europe is still marginal.
View Article and Find Full Text PDFArticle Synopsis
- Patients with community-acquired pneumonia (CAP) experience a harmful immune response that impacts survival rates, and the role of microRNAs (miRNAs) as potential biomarkers in this context is explored.
- A study surveyed 153 patients hospitalized with CAP, examining clinical data and miRNA levels in their blood to assess the link between these molecules and 30-day mortality outcomes.
- Results indicated that higher levels of miR-146a and miR-16-5p are associated with lower mortality, suggesting that these miRNAs can serve as reliable biomarkers for predicting better prognosis in CAP patients.
Background: Patients with coronavirus disaese 2019 (COVID-19) can develop a cytokine release syndrome that eventually leads to acute respiratory distress syndrome requiring invasive mechanical ventilation (IMV). Because IL-6 is a relevant cytokine in acute respiratory distress syndrome, the blockade of its receptor with tocilizumab (TCZ) could reduce mortality and/or morbidity in severe COVID-19.
Objective: We sought to determine whether baseline IL-6 serum levels can predict the need for IMV and the response to TCZ.
The paradigmatic relationship between aging and atherosclerotic cardiovascular events does not apply to all patient populations. Though trisomy 21 (T21) and its phenotypic expression, Down syndrome (DS), are conditions that involve premature aging, the cardiovascular system of adults with DS appears to be particularly spared from this early senescence. Despite a higher prevalence of some classic cardiovascular risk factors in adults with DS than in the general population, such as dyslipidemia, obesity, or sedentarism, these individuals do not develop hypertension or suffer major cardiovascular events as they age.
View Article and Find Full Text PDFIntroduction: Community-acquired pneumonia (CAP) is a common serious infection. This study aimed to evaluate the prognostic utility of neutrophil count percentage (NCP) and neutrophil-lymphocyte ratio (NLR) in patients with CAP.
Methods: Retrospective study of hospitalized patients with CAP.
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View Article and Find Full Text PDFIntroduction: Gastroenterology is one of the medical specialties offered to residency training candidates each year. This project analyzes the data associated with the choice of a Gastroenterology residency program in recent years.
Material And Methods: Data related to specialty selection were obtained from official reports with regard to the allocation of residency places by the Spanish Ministry of Health, Social Services and Equality.
Introduction: The increase and persistence of inflammation in community-acquired pneumonia (CAP) patients can lead to higher mortality. Biomarkers capable of measuring this inadequate inflammatory response are likely candidates to be related with a bad outcome. We investigated the association between concentrations of several inflammatory markers and mortality of CAP patients.
View Article and Find Full Text PDFBackground: Late prognosis of Community-Acquired Pneumonia (CAP) patients is related to cardiovascular events. Persistence of inflammation-related markers, defined by high circulatory levels of interleukin 6 and 10 (IL-6/IL-10), is associated with a higher post-event mortality rate for CAP patients. However, association between these markers and other components of the immune response, and the risk of cardiovascular events, has not been adequately explored.
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