Publications by authors named "Jose-Luis Lopez-Campos"
Article Synopsis
- The study evaluates how the use of transparent capsules in dry powder inhalers influences the amount of medication inhaled by patients with chronic airway diseases.
- Researchers compared the weight of capsules before and after inhalation in 91 patients, finding that transparent capsules resulted in a significant weight decrease (30.1%) compared to opaque ones (8.6%).
- The findings highlight the importance of ensuring patients use proper inhalation techniques to maximize medication delivery.
Article Synopsis
- * An analysis of plasma samples from 40 COPD patients revealed 363 proteins, with 31 showing significant differences in levels between those who survived and those who did not after four years.
- * The study found that predictive models based on proteomic data achieved high accuracy for mortality prediction (90%) and suggested that specific protein groups related to immune response, hemostasis, and inflammation could enhance prognostic capabilities for managing COPD.
Article Synopsis
- The study investigated the differences in chronic obstructive pulmonary disease (COPD) between genders in patients with alpha-1 antitrypsin deficiency (AATD) using data from the EARCO registry.
- It analyzed 1283 AATD patients and found that while women reported less smoking and alcohol consumption, they had a higher prevalence of bronchiectasis despite better lung function.
- Results indicated that women experienced a similar symptom burden as men but had higher rates of exacerbations, suggesting that treatment approaches may need to be adjusted for female patients.
Article Synopsis
- The study investigates the PI*SS genotype's risk for lung disease in individuals with alpha-1 antitrypsin deficiency (AATD) and compares it to the more common PI*ZZ and PI*SZ genotypes.
- Using data from 1,007 participants, results indicate that individuals with the PI*SS genotype have a lower prevalence of lung diseases like COPD and emphysema compared to PI*ZZ patients, but similar rates to those with the PI*SZ genotype.
- The findings suggest that while PI*SS is linked to lower lung disease risk than PI*ZZ, it does not show a significant difference when compared to PI*SZ, despite higher serum AAT levels in the former group.
Article Synopsis
- This study analyzes lung cancer trends in Spain from 1990 to 2019, focusing on how age, period, and birth cohort affect incidence rates.
- It found that nearly 738,000 lung cancer cases were diagnosed, with an overall annual increase of 1.7%, but a rise in women’s incidence rates (2.5% annually) and a decline in men's rates (-0.6%).
- The results suggest a closing gender gap in lung cancer incidence due to decreasing smoking rates, highlighting the need for targeted prevention efforts for women and continued tobacco control measures.
Article Synopsis
- The ANTES B+ study evaluates whether adding an inhaled corticosteroid (ICS) to a combination of long-acting beta agonist (LABA) and long-acting muscarinic antagonist (LAMA) improves clinical control in GOLD B COPD patients who are still symptomatic despite current treatment.
- It will involve 1028 patients who will either continue their current LABA/LAMA regimen or switch to a new triple therapy for a year, measuring outcomes like clinical control, exacerbation rates, and lung function.
- The study is significant as it is the first to test this approach in a specific COPD patient group and to use a composite index to measure primary outcomes, with results expected by early 2026.
Article Synopsis
- The study aimed to compare the systemic proteomic profiles of frequent exacerbators (FE) and non-frequent exacerbators (NFE) among COPD patients, alongside a reference group of healthy controls (HC) and patients during an exacerbation (AE).
- Analysis included 40 stable COPD patients (20 FE and 20 NFE), and results showed 40 different proteins in FE, 10 in NFE, and 63 in AE compared to HC.
- Results indicated that FE patients had specific inflammatory dysregulations, with some proteomic changes shared with AE, while others were unique to exacerbation episodes.
Article Synopsis
- The study investigates the impact of exacerbations of Chronic Obstructive Pulmonary Disease (ECOPD) on global mortality and hospital readmission rates after hospitalization.
- The analysis included data from 65,945 COPD patients, revealing a 6.2% in-hospital mortality rate and significant post-discharge mortality and readmission rates at various intervals.
- Researchers emphasize the need for standardized management of ECOPD and suggest that policymakers prioritize funding for effective therapies to reduce the incidence of recurrent hospitalizations.
Article Synopsis
- Alpha-1 antitrypsin deficiency (AATD) is a common inherited disorder linked to chronic obstructive pulmonary disease (COPD), yet it remains underdiagnosed; a recent audit aimed to evaluate AAT testing rates among COPD patients in Spain from 2021-2022 and compare results with a similar audit from 2014-2015.! -
- The audit analyzed 4,225 COPD patients and found that 39.5% had AAT levels tested, with higher testing likelihood associated with patients under 55, those treated at specialized clinics, and those with severe COPD, while factors like higher Charlson index and lack of AATD genotyping availability were linked to lower testing rates.!
Article Synopsis
- Detecting hidden cancers in patients with unexplained venous thromboembolism (VTE) is challenging, and this study sought to explore how coagulation-related biomarkers could help.
- A study involving 214 patients with unprovoked VTE measured several biomarkers at diagnosis, finding that sP-selectin levels were significantly higher in patients with occult cancer.
- Combining high levels of sP-selectin and D-dimer can potentially identify occult cancer with up to 91% specificity, indicating these biomarkers may be useful in clinical settings, although more research is needed.
Article Synopsis
- Most clinical labs use nephelometry or turbidimetry to measure alpha-1 antitrypsin (AAT) levels because these methods are automated and precise, relying on light scattering.
- Nephelometry assesses light scattering by directly measuring the intensity of light that passes through a sample, while turbidimetry measures the reduction in light intensity due to scattering by particles.
- The effectiveness of both methods can be influenced by factors like sample concentration and the size of the particles being measured, with specific protocols and clinical applications discussed for diagnosing AAT deficiency.
Efficacy and Safety of Single-inhaler Triple Therapy Containing Dual Bronchodilator With Corticosteroids Compared to Monotherapy, Dual Therapy, or Open Triple Therapy in Moderate/Severe COPD: A Systematic Literature Review.
Juan Antonio Riesco Miranda Myriam Calle Rubio David Díaz Pérez Jose Luis López-Campos Juan Antonio Trigueros Carrero
Arch Bronconeumol
January 2024
Article Synopsis
- Lung cancer is a major global health issue, causing over 1.8 million deaths annually, with surgery being a highly effective treatment for early-stage cases.
- This study analyzed the metabolic changes in serum samples from lung cancer patients before and after surgery, using advanced techniques to compare their profiles at two time points with those of healthy individuals.
- Twenty-two metabolites were found to be altered in patients pre-surgery, with some returning to normal levels months after surgery, while others remained altered, providing valuable insights into treatment responses and potential cancer recurrence detection.
Article Synopsis
- The study focuses on improving the detection of alpha-1 antitrypsin deficiency (AATD) among patients with chronic obstructive pulmonary disease (COPD) through a systematic case detection program.
- It analyzes data from three time periods: no systematic detection (before 2013), targeted detection of specific alleles (2013-2018), and broader detection of multiple mutations (since 2018).
- Results show a significant increase in the identification of carriers and highlight the effectiveness of systematic screening in detecting AATD-related mutations over time.
Article Synopsis
- There is significant confusion regarding the correct dosage of inhaled medications, prompting a review of inhalation therapy devices.
- A systematic search identified 90 unique inhalation products, noting variations in long-acting bronchodilators and inhaled corticosteroids, with different marketing practices for dosages.
- The findings indicate that each inhaled drug may have multiple dosage forms, emphasizing the need for clinicians to be cautious when prescribing these medications.
Article Synopsis
- Lung cancer is the top cause of cancer deaths, and having chronic obstructive pulmonary disease (COPD) can heighten the risk of developing lung cancer.
- An observational study analyzed serum samples from 191 individuals to identify the presence and levels of various elements linked to these diseases.
- Results showed that the severity of COPD alters serum elemental composition and that specific elements might be used as potential biomarkers for diagnosing or predicting lung cancer, highlighting the connection between COPD and lung cancer progression.
Article Synopsis
- There is a growing emphasis on identifying Chronic Obstructive Pulmonary Disease (COPD) early to improve health outcomes and treatment effectiveness.
- The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has introduced concepts like pre-COPD and PRISm to help categorize early-stage COPD patients, but these definitions are not universally accepted.
- Clear and widely accepted definitions of early COPD are crucial for designing effective clinical trials and determining appropriate treatments for patients at risk.
Inhaled Maintenance Therapy in the Follow-Up of COPD in Outpatient Respiratory Clinics. Factors Related to Inhaled Corticosteroid Use. EPOCONSUL 2021 Audit.
Myriam Calle Rubio Marc Miravitlles José Luis López-Campos Bernardino Alcázar Navarrete Juan José Soler Cataluña
Arch Bronconeumol
November 2023
Article Synopsis
- The study aimed to analyze how inhaled maintenance therapy for COPD is prescribed based on patient risk levels and factors influencing the decision to use inhaled corticosteroids (ICS) alongside bronchodilators in real-world settings.
- A large audit called EPOCONSUL 2021 reviewed over 4,200 COPD patients across Spain, finding that 74.5% were classified as high risk.
- Results indicated that ICS were commonly prescribed for low-risk patients under specific conditions, while high-risk patients more often received triple therapy; however, adherence to guidelines in treatment adjustments during follow-ups was not consistent.
Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin.
María Torres-Durán José Luis López-Campos Myriam Calle Rubio Carmen Montero-Martínez Ana Priegue Carrera
Int J Chron Obstruct Pulmon Dis
August 2023
Article Synopsis
- The study discusses the need for self-administration of alpha-1 antitrypsin (AAT) therapy, which can improve patient quality of life by reducing the frequency of hospital visits for infusions.
- The research involved 25 experts—including pulmonologists, nurses, and pharmacists—who participated in online meetings to form recommendations about patient selection, healthcare roles, training, and logistics.
- The aim is to raise awareness of self-administration as an option for AAT therapy, enhance patient experiences, and encourage further research to optimize these programs.
Article Synopsis
- The study aims to assess tobacco use and knowledge of chronic obstructive pulmonary disease (COPD) among adults in Spain, comparing new findings to a 2011 survey.
- Based on phone interviews with over 6,500 respondents, smoking rates have declined since 2011, with current smoking at 14.7% and notable attempts to quit, especially among current smokers.
- While there is an increase in COPD awareness (32.5% of respondents knew about it), this knowledge varies by region, highlighting the need for targeted education and smoking prevention efforts, particularly for women.
Article Synopsis
- - The study investigates the frequency of rare SERPINA1 mutations to improve management strategies for alpha1 antitrypsin deficiency (AATD), based on a secondary analysis of a large sample of 30,827 individuals across six countries.
- - Researchers utilized the Progenika A1AT Genotyping Test, discovering that 2.6% of cases had rare alleles, with the majority being heterozygous and a few homozygous; however, some expected mutations were not detected in the tested samples.
- - The findings reveal new insights into the distribution of rare alleles and suggest the need for more comprehensive testing and research to understand their pathogenic effects in different populations.
Article Synopsis
- Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder linked to lung diseases like COPD, and its prevalence in Colombia is unclear despite recommendations for testing all COPD patients.
- A study was conducted with 1,107 adult COPD patients across seven care centers in Colombia to assess AATD-related mutations using samples from the oral mucosa.
- Results revealed that 13.01% of patients had genetic mutations, with only 2.07% having AATD-related mutations, highlighting the need for better diagnosis and awareness of this condition.